Associated Papers
A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate.
Loo TW et al.
Biochemical Pharmacology, 2017
Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly.
Tombline G et al.
The Journal of Biological Chemistry, 2004
Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).
Sauna ZE et al.
Biochemistry, 2002
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