Associated Papers
In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein.
Futamata R et al.
The Journal of Biological Chemistry, 2020
Active transport of rhodamine 123 by the human multidrug transporter P-glycoprotein involves two independent outer gates.
Nasim F et al.
Pharmacology Research & Perspectives, 2020
Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.
Maamari D et al.
Pharmacogenomics and Personalized Medicine, 2020
A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate.
Loo TW et al.
Biochemical Pharmacology, 2017
A single active catalytic site is sufficient to promote transport in P-glycoprotein.
Bársony O et al.
Scientific Reports, 2016
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.
Tainton KM et al.
Cell Death and Differentiation, 2004
Transition-state formation in ATPase-negative mutants of human MDR1 protein.
Szakács G et al.
Biochemical and Biophysical Research Communications, 2000
Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein.
Takada Y et al.
Biochimica Et Biophysica Acta, 1998
Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains.
Szabó K et al.
The Journal of Biological Chemistry, 1998
Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein.
Goodfellow HR et al.
The Journal of Biological Chemistry, 1996
Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.
Loo TW et al.
The Journal of Biological Chemistry, 1995
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
Gill DR et al.
Cell, 1992
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