Varaico: Literature-Extracted Genetic Variants

Gene:ABCB1
Variant:p.W232C
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ABCB1

NM_001348946.2:p.W232C

Associated Papers

The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants.

Loo TW et al.

Biochemistry, 2011

Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein.

Gruol DJ et al.

Molecular Pharmacology, 2002

Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane.

Loo TW et al.

The Journal of Biological Chemistry, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."