Varaico: Literature-Extracted Genetic Variants

Gene:ABCB1
Variant:p.T199R
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ABCB1

NM_001348946.2:p.T199R

Associated Papers

Biochemical studies on the structure-function relationship of major drug transporters in the ATP-binding cassette family and solute carrier family.

Hong M

Advanced Drug Delivery Reviews, 2017

Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis.

Loo TW et al.

The Journal of Biological Chemistry, 2009

Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

Loo TW et al.

The Journal of Biological Chemistry, 2008

Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.

Loo TW et al.

The Journal of Biological Chemistry, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."