Varaico: Literature-Extracted Genetic Variants

Gene:ABCB1
Variant:p.R113K
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ABCB1

NM_001348946.2:p.R113K

Associated Papers

Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling.

Song J et al.

Molecular Pharmacology, 2001

The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.

Gruol DJ et al.

Molecular Pharmacology, 2001

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

Zhang X et al.

The Journal of Biological Chemistry, 1995

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."