Varaico: Literature-Extracted Genetic Variants

Gene:ABCB1
Variant:p.N21D
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ABCB1

NM_001348946.2:p.N21D

Associated Papers

The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants.

Thorsen SV et al.

Basic & Clinical Pharmacology & Toxicology, 2025

Optimizing tacrolimus dosage in post-renal transplantation using DoseOptimal framework: profiling CYP3A5 genetic variants for interpretability.

Raval CU et al.

International Journal of Clinical Pharmacy, 2025

In vitro identification of decreased function genetic variants of ABCB1.

Suominen L et al.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2025

Mapping the Role of P-gp in Multidrug Resistance: Insights from Recent Structural Studies.

Tia ST et al.

International Journal of Molecular Sciences, 2025

ABCB1 gene single nucleotide variants and haplotypes in atrial fibrillation patients experiencing adverse events on direct oral anticoagulation: a whole gene exome sequencing study.

Samoš M et al.

Journal of Cardiovascular Pharmacology, 2025

ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein.

Qin W et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2024

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview.

Perini JA et al.

Toxics, 2024

38535959 (PubMed )
Supplement: toxics-12-00226-s001.zip › toxics-2905208-supplementary.pdf

Pharmacogenetics of anxiety and depression in Alzheimer's disease.

Cacabelos R et al.

Pharmacogenomics, 2023

Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.

Silgado-Guzmán DF et al.

Frontiers in Pharmacology, 2022

35846994 (PubMed )
Supplement: Table1.xlsx › Hoja1

The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients.

Chen Z et al.

Pharmacological Reports : Pr, 2021

Reviewing pharmacogenetics to advance precision medicine for opioids.

Magarbeh L et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2021

Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs.

Badary OA

The Pharmacogenomics Journal, 2021

Pharmacogenetics of the Central Nervous System-Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia.

Sági JC et al.

Cancers, 2021

34066083 (PubMed )
Supplement: cancers-13-02333-s001.zip › Supplementary_Tables.xlsx › Table_S1a

Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use.

Ramli FF

Bosnian Journal of Basic Medical Sciences, 2021

ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?

Bruckmueller H et al.

Expert Opinion on Drug Metabolism & Toxicology, 2021

Influence of CYP3A polymorphisms on tacrolimus pharmacokinetics in kidney transplant recipients.

Hannachi I et al.

The Pharmacogenomics Journal, 2021

Contribution of rare genetic variants to drug response in absence epilepsy.

Myers KA et al.

Epilepsy Research, 2021

Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.

Aboul-Soud MAM et al.

Saudi Journal of Biological Sciences, 2021

33424349 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response.

Hlaváč V et al.

International Journal of Molecular Sciences, 2020

33334016 (PubMed )
Supplement: ijms-21-09556-s001.pdf

Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia.

Fontana D et al.

Hemasphere, 2020

33196013 (PubMed )
Supplement: hs9-4-e497-s005.xlsx › Sheet1

Ethnogeographic and inter-individual variability of human ABC transporters.

Xiao Q et al.

Human Genetics, 2020

A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions.

Calderon-Ospina CA et al.

Pharmacogenomics and Personalized Medicine, 2020

The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome.

Coller JK et al.

British Journal of Clinical Pharmacology, 2019

Targeted next generation sequencing as a tool for precision medicine.

Gulilat M et al.

Bmc Medical Genomics, 2019

31159795 (PubMed )
Supplement: 12920_2019_527_MOESM1_ESM.xlsx › Table_S6

Pharmacogenetics of Membrane Transporters of Tacrolimus in Solid Organ Transplantation.

Tron C et al.

Clinical Pharmacokinetics, 2019

Influence of ABCB1 C3435T and C1236T gene polymorphisms on tumour response to docetaxel-based neo-adjuvant chemotherapy in locally advanced breast cancer patients of South India.

Priyadarshini R et al.

Journal of Clinical Pharmacy and Therapeutics, 2019

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Canet LM et al.

The Pharmacogenomics Journal, 2019

Effect of tacrolimus dispositional genetics on acute rejection in the first 2 weeks and estimated glomerular filtration rate in the first 3 months following kidney transplantation.

Hu R et al.

Pharmacogenetics and Genomics, 2019

ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics.

López-Fernández LA

Journal of Personalized Medicine, 2018

30563187 (PubMed )
Supplement: jpm-08-00040-s001.xlsx › Hoja1

ABCB1 1199G>A Polymorphism Affects the Intracellular Accumulation of Antidepressants in LLC-PK1 Recombinant Cell Lines.

Gao YL et al.

Dna and Cell Biology, 2018

CYP3A5*3 and ABCB1 61A>G Significantly Influence Dose-adjusted Trough Blood Tacrolimus Concentrations in the First Three Months Post-Kidney Transplantation.

Hu R et al.

Basic & Clinical Pharmacology & Toxicology, 2018

Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma.

Sági JC et al.

Bmc Cancer, 2018

29970035 (PubMed )
Supplement: 12885_2018_4629_MOESM1_ESM.xlsx › Munka1

Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia.

Zakerska-Banaszak O et al.

Scientific Reports, 2017

Relationship Between ABCB1 Polymorphisms and Cold Pain Sensitivity Among Healthy Opioid-naive Malay Males.

Zahari Z et al.

Pain Practice : the Official Journal of World Institute of Pain, 2017

Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.

Angelini S et al.

Anticancer Research, 2017

Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.

Hegyi M et al.

Oncotarget, 2017

Pharmacogenetics of irinotecan, doxorubicin and docetaxel transporters in Asian and Caucasian cancer patients: a comparative review.

Chen S et al.

Drug Metabolism Reviews, 2016

A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia.

Lu C et al.

Cold Spring Harbor Molecular Case Studies, 2016

27148581 (PubMed )
Supplement: supp_2.1.a000687_Supp_Table_2.xlsx › germline.missense

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment.

Tulsyan S et al.

Pharmacogenomics and Personalized Medicine, 2016

Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort.

Vandenberghe F et al.

Clinical Pharmacokinetics, 2015

Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.

Frederiks CN et al.

Cancer Treatment Reviews, 2015

Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation.

Ruiz J et al.

International Journal of Molecular Sciences, 2015

ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression.

Ray A et al.

The Pharmacogenomics Journal, 2015

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.

Wolking S et al.

Clinical Pharmacokinetics, 2015

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.

Abedalthagafi MS et al.

Oncotarget, 2014

25347344 (PubMed )
Supplement: oncotarget-05-10596-s002.xlsx › Table_S4

MDR1 C3435T polymorphism associated with the development of clinical features in Behçet's disease in Iranian Azeri Turkish patients.

Bonyadi M et al.

International Journal of Dermatology, 2014

Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.

Abraham JE et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2014

24599932 (PubMed )
Supplement: 10780432ccr133232-sup-ccr-13-3232tabs1-5figs1-2.pdf

Genotype and allele frequencies of drug-metabolizing enzymes and drug transporter genes affecting immunosuppressants in the Spanish white population.

Bosó V et al.

Therapeutic Drug Monitoring, 2014

Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.

Dennis BB et al.

Plos One, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."