Varaico: Literature-Extracted Genetic Variants

Gene:ABCC1
Variant:p.R723Q
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ABCC1

NM_004996.4:p.R723Q

Associated Papers

The influence of naturally occurring and in silico-informed mutations of MRP1/ABCC1 on the transport of arsenic triglutathione.

Li W et al.

Chemico-biological Interactions, 2026

Structural and functional implications of ABCC1 variants on clinical statin response.

Crispim Tropéia N et al.

Journal of Biomolecular Structure & Dynamics, 2025

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.

Sharma P et al.

Journal of Biochemical and Molecular Toxicology, 2023

Impact of ABCB1, ABCC1, ABCC2, and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum-based doublet chemotherapy.

Sharma P et al.

The Journal of Gene Medicine, 2023

Genetic analysis and prenatal diagnosis of short-rib thoracic dysplasia 3 with or without polydactyly caused by compound heterozygous variants of DYNC2H1 gene in four Chinese families.

Fang Y et al.

Frontiers in Genetics, 2023

37007936 (PubMed )
Supplement: Table4.XLS › WES_20220309_T7.JXPES22030004.t

Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholestasis of pregnancy.

Liu X et al.

Frontiers in Genetics, 2022

36046230 (PubMed )
Supplement: Table3.XLSX › Sheet1

Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.

Aboul-Soud MAM et al.

Saudi Journal of Biological Sciences, 2021

33424349 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Identification of New Tumor-Related Gene Mutations in Chinese Gastrointestinal Stromal Tumors.

Feng Y et al.

Frontiers in Cell and Developmental Biology, 2021

34805171 (PubMed )
Supplement: Table6.XLS › 49_sample_result

Identification of Novel Rare ABCC1 Transporter Mutations in Tumor Biopsies of Cancer Patients.

Kadioglu O et al.

Cells, 2020

Polymorphisms of genes encoding drug transporters or cytochrome P450 enzymes and association with clinical response in cancer patients: a systematic review.

Kulma I et al.

Cancer Chemotherapy and Pharmacology, 2019

Targeted next generation sequencing as a tool for precision medicine.

Gulilat M et al.

Bmc Medical Genomics, 2019

31159795 (PubMed )
Supplement: 12920_2019_527_MOESM1_ESM.xlsx › Table_S6

Novel association between heterozygous genotype of single nucleotide polymorphism C218T in drug transporter ABCC1 gene and increased risk of colon cancer.

Abdulkhaleq MM et al.

Saudi Medical Journal, 2019

ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics.

López-Fernández LA

Journal of Personalized Medicine, 2018

30563187 (PubMed )
Supplement: jpm-08-00040-s001.xlsx › Hoja1

Pharmacogenetics of irinotecan, doxorubicin and docetaxel transporters in Asian and Caucasian cancer patients: a comparative review.

Chen S et al.

Drug Metabolism Reviews, 2016

Genetic variation of the ABC transporter gene ABCC1 (Multidrug resistance protein 1-MRP1) in the Polish population.

Słomka M et al.

Bmc Genetics, 2015

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.

Simeon V et al.

International Journal of Molecular Sciences, 2015

Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients.

Au A et al.

Journal of Clinical Pharmacy and Therapeutics, 2014

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: a DMET Plus microarray assessment.

Yi S et al.

Pharmacogenetics and Genomics, 2014

The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients.

Li XP et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2014

Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.

Kunická T et al.

Plos One, 2014

Structural and energetic analyses of SNPs in drug targets and implications for drug therapy.

Sun HY et al.

Journal of Chemical Information and Modeling, 2013

24304102 (PubMed )
Supplement: ci400457v_si_001.xls › Sheet1

Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1.

Conseil G et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2013

Genetic association analysis of transporters identifies ABCC2 loci for seizure control in women with epilepsy on first-line antiepileptic drugs.

Grover S et al.

Pharmacogenetics and Genomics, 2012

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.

Yin J et al.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 2011

ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population.

Yin JY et al.

Clinical and Experimental Pharmacology & Physiology, 2011

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

Pajic M et al.

Pharmacogenetics and Genomics, 2011

Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma.

Zhao J et al.

World Journal of Gastroenterology, 2010

Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin.

Buda G et al.

Annals of Hematology, 2010

MRP1 polymorphisms associated with citalopram response in patients with major depression.

Lee SH et al.

Journal of Clinical Psychopharmacology, 2010

Pharmacogenetics of membrane transporters: an update on current approaches.

Sissung TM et al.

Molecular Biotechnology, 2010

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population.

Yin JY et al.

Pharmacogenetics and Genomics, 2009

Pharmacogenetics of membrane transporters: a review of current approaches.

Sissung TM et al.

Methods in Molecular Biology (clifton, N.j.), 2008

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

Cascorbi I

Pharmacology & Therapeutics, 2006

Japanese single nucleotide polymorphism database for 267 possible drug-related genes.

Iida A et al.

Cancer Science, 2006

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).

Létourneau IJ et al.

Pharmacogenetics and Genomics, 2005

The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overview.

Ferraro TN et al.

Epilepsy & Behavior : E&b, 2005

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.

Conseil G et al.

Pharmacogenetics and Genomics, 2005

Predicting drug response and toxicity based on gene polymorphisms.

Robert J et al.

Critical Reviews in Oncology/hematology, 2005

Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association studies.

Wang H et al.

Annals of Human Genetics, 2004

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects.

Moriya Y et al.

Biological & Pharmaceutical Bulletin, 2002

[SNP collection, pharmacogenomics, and the future of drug therapy].

Iida A et al.

Gan to Kagaku Ryoho. Cancer & Chemotherapy, 2002

Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR.

Saito S et al.

Journal of Human Genetics, 2002

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

Ito S et al.

Pharmacogenetics, 2001

Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer.

Obata H et al.

Anticancer Research, 0

Selected Genetic Polymorphisms Associated with Hypoxia and Multidrug Resistance in Monoclonal Gammopathies Patients.

Almasi M et al.

Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."