Varaico: Literature-Extracted Genetic Variants

Gene:ABCC2
Variant:p.R412G
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ABCC2

NM_000392.5:p.R412G

Associated Papers

In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants.

Kölz C et al.

British Journal of Pharmacology, 2024

A recurrent ABCC2 p.G693R mutation resulting in loss of function of MRP2 and hyperbilirubinemia in Dubin-Johnson syndrome in China.

Wu L et al.

Orphanet Journal of Rare Diseases, 2020

32183854 (PubMed )
Supplement: 13023_2020_1346_MOESM1_ESM.docx

Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes.

Wang LL et al.

Basic & Clinical Pharmacology & Toxicology, 2011

Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.

Grant SF et al.

Expert Review of Molecular Diagnostics, 2007

The apical conjugate efflux pump ABCC2 (MRP2).

Nies AT et al.

Pflugers Archiv : European Journal of Physiology, 2007

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

Cascorbi I

Pharmacology & Therapeutics, 2006

Identification of a novel 974C-->G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids.

Corpechot C et al.

The American Journal of Gastroenterology, 2006

Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.

Joerger M et al.

British Journal of Clinical Pharmacology, 2006

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.

Bosch TM et al.

Molecular Diagnosis & Therapy, 2006

A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination.

Hulot JS et al.

Pharmacogenetics and Genomics, 2005

Pharmacogenetics and the concept of individualized medicine.

Shastry BS

The Pharmacogenomics Journal, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."