Associated Papers
Elucidating the link between NS-SNP-Induced protein conformational changes and drug resistance in Klebsiella pneumoniae.
Liu W et al.
Archives of Microbiology, 2026
The influence of naturally occurring and in silico-informed mutations of MRP1/ABCC1 on the transport of arsenic triglutathione.
Li W et al.
Chemico-biological Interactions, 2026
Genetic Analysis of Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH): A Single-Center Observational Study.
Bereczky Z et al.
Genes, 2025
Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics.
Mykkänen AJH et al.
Clinical Pharmacology and Therapeutics, 2025
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4).
Mailloux J et al.
Pharmacogenetics and Genomics, 2022
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia.
Fan POL et al.
Pediatric Hematology and Oncology, 2022
Augustine Blood Group System and Equilibrative Nucleoside Transporter 1.
Daniels G
Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie, 2022
Genetic landscape of 125 pharmacogenes in Chinese from the Chinese Millionome Database.
Qi G et al.
Scientific Reports, 2021
The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.
Mikdar M et al.
Blood, 2021
Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics.
Becerra E et al.
Molecules (basel, Switzerland), 2021
Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease.
Wang Y et al.
Frontiers in Genetics, 2021
Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients.
Chamnanphon M et al.
Pharmacogenomics and Personalized Medicine, 2021
Genetic Diversity in Drug Transporters: Impact in African Populations.
Rajman I et al.
Clinical and Translational Science, 2020
Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation.
Azouzi S et al.
Blood, 2020
The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics.
Schwarz UI et al.
Cold Spring Harbor Perspectives in Medicine, 2019
A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance.
Tsukamoto M et al.
Cells, 2019
ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics.
López-Fernández LA
Journal of Personalized Medicine, 2018
Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.
Salvador-Martín S et al.
Pharmacological Research, 2018
Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease.
Schiff ER et al.
Human Genetics, 2018
Structural patterns of the human ABCC4/MRP4 exporter in lipid bilayers rationalize clinically observed polymorphisms.
Chantemargue B et al.
Pharmacological Research, 2018
Quantitative Evaluation of Drug Resistance Profile of Cells Expressing Wild-Type or Genetic Polymorphic Variants of the Human ABC Transporter ABCC4.
Tsukamoto M et al.
International Journal of Molecular Sciences, 2017
Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.
Tanner C et al.
Arthritis & Rheumatology (hoboken, N.j.), 2017
Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.
Banerjee M et al.
Biochemical Pharmacology, 2016
Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.
Molnár J et al.
Plos One, 2016
Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.
Tanaka Y et al.
British Journal of Haematology, 2015
Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia.
Tanaka Y et al.
The Pharmacogenomics Journal, 2015
Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.
Gao LC et al.
European Journal of Clinical Pharmacology, 2015
TBX1 mutation identified by exome sequencing in a Japanese family with 22q11.2 deletion syndrome-like craniofacial features and hypocalcemia.
Ogata T et al.
Plos One, 2014
Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.
Wang J et al.
Plos One, 2014
ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort.
Zhu P et al.
Plos One, 2013
Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes.
Wang LL et al.
Basic & Clinical Pharmacology & Toxicology, 2011
Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.
Krishnamurthy P et al.
Cancer Research, 2008
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
Abla N et al.
The Journal of Pharmacology and Experimental Therapeutics, 2008
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.
Janke D et al.
Human Mutation, 2008
Variability in human hepatic MRP4 expression: influence of cholestasis and genotype.
Gradhand U et al.
The Pharmacogenomics Journal, 2008
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.
Izzedine H et al.
The Journal of Infectious Diseases, 2006