Associated Papers
Exploring the effect of intracellular loop 1 genetic variants in human ABCG2 on transport activity and protein abundance.
Sjöstedt N et al.
Drug Metabolism and Pharmacokinetics, 2025
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters.
Baril SA et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023
A Pan-Cancer Landscape of ABCG2 across Human Cancers: Friend or Foe?
Lyu C et al.
International Journal of Molecular Sciences, 2022
Multidrug efflux transporter ABCG2: expression and regulation.
Kukal S et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Medically Important Alterations in Transport Function and Trafficking of ABCG2.
Homolya L
International Journal of Molecular Sciences, 2021
The ABCG2/BCRP transporter and its variants - from structure to pathology.
Sarkadi B et al.
Febs Letters, 2020
The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid.
Khunweeraphong N et al.
Nature Communications, 2019
ABCG2/BCRP: variants, transporter interaction profile of substrates and inhibitors.
Safar Z et al.
Expert Opinion on Drug Metabolism & Toxicology, 2019
Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics.
Heyes N et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2018
Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2.
Sjöstedt N et al.
Pharmaceutical Research, 2017
Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan.
Deppe S et al.
Biochemical and Biophysical Research Communications, 2014
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.
Noguchi K et al.
Pharmacogenomics and Personalized Medicine, 2014
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.
Nakanishi T et al.
Chinese Journal of Cancer, 2012
Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts.
Nakagawa H et al.
Journal of Pharmaceutical Sciences, 2011
Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes.
Wang LL et al.
Basic & Clinical Pharmacology & Toxicology, 2011
BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization.
Shigeta J et al.
Cancer Science, 2010
Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene.
Kawahara H et al.
Cancer Science, 2010
Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
Ishikawa T et al.
Advances in Pharmacological Sciences, 2010
Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.
Furukawa T et al.
Pharmaceutical Research, 2009
Quality control of human ABCG2 protein in the endoplasmic reticulum: ubiquitination and proteasomal degradation.
Wakabayashi-Nakao K et al.
Advanced Drug Delivery Reviews, 2009
Human ABC transporters ABCG2 (BCRP) and ABCG4.
Koshiba S et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008
Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.
Nakagawa H et al.
The Biochemical Journal, 2008
The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein.
Yoshioka S et al.
Pharmaceutical Research, 2007
Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.
Tamura A et al.
Cancer Science, 2007
Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.
Tamura A et al.
Molecular Pharmacology, 2006
The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology.
Cervenak J et al.
Cancer Letters, 2006
Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system.
Tamura A et al.
Journal of Experimental Therapeutics & Oncology, 2006
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Itoda M et al.
Drug Metabolism and Pharmacokinetics, 2003