Associated Papers
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Chen C et al.
Cell Metabolism, 2024
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance.
Gose T et al.
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2024
The net electrostatic potential and hydration of ABCG2 affect substrate transport.
Gose T et al.
Nature Communications, 2023
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters.
Baril SA et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023
Nucleotide binding is the critical regulator of ABCG2 conformational transitions.
Gyöngy Z et al.
Elife, 2023
A Pan-Cancer Landscape of ABCG2 across Human Cancers: Friend or Foe?
Lyu C et al.
International Journal of Molecular Sciences, 2022
Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8.
Farhat D et al.
Journal of Molecular Biology, 2022
ABCG2/BCRP transport mechanism revealed through kinetically excited targeted molecular dynamics simulations.
Dudas B et al.
Computational and Structural Biotechnology Journal, 2022
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Yu Q et al.
Nature Communications, 2021
The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations.
Nagy T et al.
Cellular and Molecular Life Sciences : Cmls, 2021
The Structure and Mechanism of Drug Transporters.
Roberts AG
Methods in Molecular Biology (clifton, N.j.), 2021
What monomeric nucleotide binding domains can teach us about dimeric ABC proteins.
Ford RC et al.
Febs Letters, 2020
3D structure of the transporter ABCG2-What's new?
Eckenstaler R et al.
British Journal of Pharmacology, 2020
Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps.
Banerjee A et al.
Biochimica Et Biophysica Acta. Biomembranes, 2020
Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.
Kapoor P et al.
International Journal of Molecular Sciences, 2020
Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models.
Lusvarghi S et al.
F1000research, 2020
Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Manolaridis I et al.
Nature, 2018
Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.
Cox MH et al.
The Biochemical Journal, 2018
Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter.
László L et al.
Plos One, 2016
Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.
Haider AJ et al.
Bioscience Reports, 2015
Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.
Haider AJ et al.
Plos One, 2011
Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport.
Hou YX et al.
Biochemistry, 2009