Varaico: Literature-Extracted Genetic Variants

Gene:ABCG2
Variant:p.I206L
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ABCG2

NM_004827.3:p.I206L

Associated Papers

Variants of the ABCG2 gene in Mexican mestizo patients with prostate cancer.

Mimendi-Aguilar GM et al.

Cellular and Molecular Biology (noisy-le-grand, France), 2025

Genomic characterization of clinically significant blood group variants in Aboriginal Australians.

Jadhao S et al.

Blood Transfusion = Trasfusione Del Sangue, 2024

38557323 (PubMed )
Supplement: BLT-22-464_Supplementary_Content.pdf

In vitro identification of decreased function phenotype ABCG2 variants.

Suominen L et al.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2023

Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians.

Jadhao S et al.

Blood Advances, 2022

35420653 (PubMed )
Supplement: mmc1.xlsx › Supplementary_table3

Multidrug efflux transporter ABCG2: expression and regulation.

Kukal S et al.

Cellular and Molecular Life Sciences : Cmls, 2021

Medically Important Alterations in Transport Function and Trafficking of ABCG2.

Homolya L

International Journal of Molecular Sciences, 2021

The ABCG2/BCRP transporter and its variants - from structure to pathology.

Sarkadi B et al.

Febs Letters, 2020

Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics.

Heyes N et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2018

Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.

Noguchi K et al.

Pharmacogenomics and Personalized Medicine, 2014

Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.

Nakanishi T et al.

Chinese Journal of Cancer, 2012

Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models.

Real R et al.

Journal of Animal Science, 2011

Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.

Moitra K et al.

Drug Metabolism and Drug Interactions, 2011

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.

Kelly L et al.

Protein Science : a Publication of the Protein Society, 2010

Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.

Ishikawa T et al.

Advances in Pharmacological Sciences, 2010

Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.

Noguchi K et al.

Advanced Drug Delivery Reviews, 2009

Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.

Merino G et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009

Pharmacogenomic importance of ABCG2.

Cusatis G et al.

Pharmacogenomics, 2008

Human ABC transporters ABCG2 (BCRP) and ABCG4.

Koshiba S et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008

ABCG2: structure, function and role in drug response.

Polgar O et al.

Expert Opinion on Drug Metabolism & Toxicology, 2008

The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein.

Yoshioka S et al.

Pharmaceutical Research, 2007

Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics.

Deeken JF et al.

Anti-cancer Drugs, 2007

Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

Tamura A et al.

Molecular Pharmacology, 2006

Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.

Yanase K et al.

Cancer Letters, 2006

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology.

Cervenak J et al.

Cancer Letters, 2006

Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system.

Tamura A et al.

Journal of Experimental Therapeutics & Oncology, 2006

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.

Sakurai A et al.

Expert Opinion on Pharmacotherapy, 2005

The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overview.

Ferraro TN et al.

Epilepsy & Behavior : E&b, 2005

Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.

Vethanayagam RR et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2005

High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

Ishikawa T et al.

Methods in Enzymology, 2005

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

Zamber CP et al.

Pharmacogenetics, 2003

Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.

Itoda M et al.

Drug Metabolism and Pharmacokinetics, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."