Varaico: Literature-Extracted Genetic Variants

Gene:ABCG2
Variant:p.T153M
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ABCG2

NM_004827.3:p.T153M

Associated Papers

The role of ABCG2 in health and disease: Linking cancer therapy resistance and other disorders.

El-Ashmawy NE et al.

Life Sciences, 2025

Understanding the impact of ABCG2 polymorphisms on drug pharmacokinetics: focus on rosuvastatin and allopurinol.

Kasten A et al.

Expert Opinion on Drug Metabolism & Toxicology, 2024

Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance.

Fan W et al.

Biomolecules, 2024

Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout.

Vávra J et al.

Disease Markers, 2024

Multidrug efflux transporter ABCG2: expression and regulation.

Kukal S et al.

Cellular and Molecular Life Sciences : Cmls, 2021

ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?

Bruckmueller H et al.

Expert Opinion on Drug Metabolism & Toxicology, 2021

Medically Important Alterations in Transport Function and Trafficking of ABCG2.

Homolya L

International Journal of Molecular Sciences, 2021

The ABCG2/BCRP transporter and its variants - from structure to pathology.

Sarkadi B et al.

Febs Letters, 2020

Evaluation of the Influence of Genetic Variants of SLC2A9 (GLUT9) and SLC22A12 (URAT1) on the Development of Hyperuricemia and Gout.

Pavelcova K et al.

Journal of Clinical Medicine, 2020

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter.

Zámbó B et al.

Cellular and Molecular Life Sciences : Cmls, 2020

Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.

Mózner O et al.

Cells, 2019

Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort.

Toyoda Y et al.

Cells, 2019

Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics.

Heyes N et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2018

Functional non-synonymous variants of ABCG2 and gout risk.

Stiburkova B et al.

Rheumatology (oxford, England), 2017

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.

Bruhn O et al.

Expert Opinion on Drug Metabolism & Toxicology, 2014

Molecular analysis of immunized Jr(a-) or Lan- patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a-) and Lan- phenotypes.

Haer-Wigman L et al.

Transfusion, 2014

Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.

Noguchi K et al.

Pharmacogenomics and Personalized Medicine, 2014

Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.

Ishikawa T et al.

Advances in Pharmacological Sciences, 2010

Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.

Noguchi K et al.

Advanced Drug Delivery Reviews, 2009

Human ABC transporters ABCG2 (BCRP) and ABCG4.

Koshiba S et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008

The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein.

Yoshioka S et al.

Pharmaceutical Research, 2007

Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

Tamura A et al.

Molecular Pharmacology, 2006

Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.

Yanase K et al.

Cancer Letters, 2006

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology.

Cervenak J et al.

Cancer Letters, 2006

Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system.

Tamura A et al.

Journal of Experimental Therapeutics & Oncology, 2006

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.

Sakurai A et al.

Expert Opinion on Pharmacotherapy, 2005

High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

Ishikawa T et al.

Methods in Enzymology, 2005

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

Mizuarai S et al.

International Journal of Cancer, 2004

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