Varaico: Literature-Extracted Genetic Variants

Gene:ABL1
Variant:p.K294E
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ABL1

NM_005157.6:p.K294E

Associated Papers

Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing.

Jung Y et al.

Nature Biomedical Engineering, 2025

Asciminib resistance of a new BCR::ABL1 p.I293_K294insSSLRD mutant detected in a Ph + ALL patient.

Cullot G et al.

Annals of Hematology, 2025

Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor.

Liu H et al.

European Journal of Medicinal Chemistry, 2022

Development of asciminib, a novel allosteric inhibitor of BCR-ABL1.

Réa D et al.

Critical Reviews in Oncology/hematology, 2022

Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia.

Janic D et al.

Journal of Medical Biochemistry, 2020

Next-generation sequencing for sensitive detection of BCR-ABL1 mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients.

Soverini S et al.

Oncotarget, 2016

26980736 (PubMed )
Supplement: oncotarget-07-21982-s001.pdf

Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.

Jiang X et al.

Journal of the National Cancer Institute, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."