Varaico: Literature-Extracted Genetic Variants

Gene:ACE
Variant:p.Y453F
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ACE

NM_000789.4:p.Y453F

Associated Papers

Modeling the Mutational Effects on Biochemical Phenotypes of SARS-CoV-2 Using Molecular Fields.

Wang B et al.

Biomolecules, 2025

Association of RBD mutations with COVID-19 disease severity in the Iranian population.

Mondeali M et al.

Virus Genes, 2025

Exploring the Intrinsic Structural Plasticity and Conformational Dynamics of Human Beta Coronavirus Spike Glycoproteins.

Ferreira E Silva Y et al.

Journal of Chemical Information and Modeling, 2025

Molecular dynamics of SARS-CoV-2 omicron variants from Philippine isolates against hesperidin as spike protein inhibitor.

Santos JAA et al.

Biophysical Chemistry, 2025

Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.

Roederer AL et al.

Cell Reports. Medicine, 2024

Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic Epitopes.

Zornikova K et al.

International Journal of Molecular Sciences, 2024

Revealing the Molecular Interactions between Human ACE2 and the Receptor Binding Domain of the SARS-CoV-2 Wild-Type, Alpha and Delta Variants.

Hognon C et al.

International Journal of Molecular Sciences, 2023

Role of spike compensatory mutations in the interspecies transmission of SARS-CoV-2.

Frutos R et al.

One Health (amsterdam, Netherlands), 2022

Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test case.

Mehra R et al.

European Biophysics Journal : Ebj, 2022

Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants.

Su C et al.

Journal of Virology, 2022

Nanomechanical analysis of SARS-CoV-2 variants and predictions of infectiousness and lethality.

Hu Y et al.

Soft Matter, 2022

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape.

Makowski EK et al.

Plos Computational Biology, 2022

Comparative structural analyses of selected spike protein-RBD mutations in SARS-CoV-2 lineages.

Roy U

Immunologic Research, 2022

Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics development.

Guruprasad K

Current Research in Structural Biology, 2022

35156058 (PubMed )
Supplement: mmc1.docx

The biological and clinical significance of emerging SARS-CoV-2 variants.

Tao K et al.

Nature Reviews. Genetics, 2021

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants.

Gupta D et al.

Cellular and Molecular Life Sciences : Cmls, 2021

SARS-CoV-2 Variants, RBD Mutations, Binding Affinity, and Antibody Escape.

Yang L et al.

International Journal of Molecular Sciences, 2021

Reply to Lassaunière: On the functional characterization of the Y453F RBD variant found in cluster 5 SARS-CoV-2.

Bayarri-Olmos R et al.

The Journal of Biological Chemistry, 2021

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants.

Upadhyay V et al.

The Journal of Biological Chemistry, 2021

Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.

Lennerstrand J et al.

Viruses, 2021

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.

Pegu A et al.

Science (new York, N.y.), 2021

34385356 (PubMed )
Supplement: science.abj4176.v1.pdf

SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.

Cai HY et al.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2021

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability.

Verma J et al.

Virology, 2021

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.

Motozono C et al.

Cell Host & Microbe, 2021

34171266 (PubMed )
Supplement: mmc8.pdf

SARS-CoV-2 receptor-binding mutations and antibody contact sites.

Mejdani M et al.

Antibody Therapeutics, 2021

Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.

Chaqroun A et al.

Viruses, 2021

The Spike of Concern-The Novel Variants of SARS-CoV-2.

Winger A et al.

Viruses, 2021

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity.

Gobeil SM et al.

Biorxiv : the Preprint Server for Biology, 2021

Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69-V70, France, August to December 2020.

Bal A et al.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 2021

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.

Starr TN et al.

Biorxiv : the Preprint Server for Biology, 2020

In Silico Prediction of New Mutations That Can Improve the Binding Abilities Between 2019-nCoV Coronavirus and Human ACE2.

Fang S et al.

Ieee/acm Transactions on Computational Biology and Bioinformatics, 0

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization.

Bayarri-Olmos R et al.

The Journal of Biological Chemistry, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."