Varaico: Literature-Extracted Genetic Variants

Gene:ACE2
Variant:p.R708W
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ACE2

NM_001371415.1:p.R708W

Associated Papers

Non-synonymous Single Nucleotide Polymorphisms in Human ACE2 Gene May Affect the Infectivity of SARS-CoV-2 Omicron Subvariants.

Samanta A et al.

Current Pharmaceutical Design, 2023

Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.

Talebi T et al.

Genetics Research, 2023

Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation.

Rodriguez JA et al.

Chemico-biological Interactions, 2022

36336003 (PubMed )
Supplement: mmc1.pdf

Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish population.

Duman N et al.

Journal of Medical Virology, 2022

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking.

Badawi S et al.

Human Genomics, 2022

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.

Zhang C et al.

Proceedings of the National Academy of Sciences of the United States of America, 2022

Human genetic basis of coronavirus disease 2019.

Deng H et al.

Signal Transduction and Targeted Therapy, 2021

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

Zhang C et al.

Medrxiv : the Preprint Server for Health Sciences, 2021

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

Zhang C et al.

Research Square, 2021

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Suryamohan K et al.

Communications Biology, 2021

33846513 (PubMed )
Supplement: 42003_2021_2030_MOESM1_ESM.pdf

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19.

Al-Mulla F et al.

Heliyon, 2021

SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study.

Lanjanian H et al.

Scientific Reports, 2021

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.

Saih A et al.

Biomed Research International, 2021

Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design.

Sorokina M et al.

Scientific Data, 2020

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).

Guo X et al.

Journal of Translational Medicine, 2020

32831104 (PubMed )
Supplement: 12967_2020_2486_MOESM1_ESM.xls › gnomAD_v2.1.1_ENSG00000130234_2

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis.

Hou Y et al.

Bmc Medicine, 2020

Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.

Li H et al.

Human Molecular Genetics, 2020

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome.

Shikov AE et al.

Frontiers in Genetics, 2020

33133145 (PubMed )
Supplement: Data_Sheet_2.xlsx › Table_S7
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."