Varaico: Literature-Extracted Genetic Variants

Gene:ACE2
Variant:p.Y207C
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ACE2

NM_001371415.1:p.Y207C

Associated Papers

Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2.

Patil S et al.

Journal of Infection and Public Health, 2022

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants.

MacGowan SA et al.

Plos Computational Biology, 2022

35235558 (PubMed )
Supplement: pcbi.1009922.s001.xlsx › Sheet1

Identification of destabilizing SNPs in SARS-CoV2-ACE2 protein and spike glycoprotein: implications for virus entry mechanisms.

Khalid Z et al.

Journal of Biomolecular Structure & Dynamics, 2022

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Suryamohan K et al.

Communications Biology, 2021

33846513 (PubMed )
Supplement: 42003_2021_2030_MOESM1_ESM.pdf

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).

Guo X et al.

Journal of Translational Medicine, 2020

32831104 (PubMed )
Supplement: 12967_2020_2486_MOESM1_ESM.xls › gnomAD_v2.1.1_ENSG00000130234_2

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome.

Shikov AE et al.

Frontiers in Genetics, 2020

33133145 (PubMed )
Supplement: Data_Sheet_2.xlsx › Table_S7
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