Varaico: Literature-Extracted Genetic Variants

Gene:ACE2
Variant:p.S43R
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ACE2

NM_001371415.1:p.S43R

Associated Papers

Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity.

Okal EF et al.

Journal of Biological Engineering, 2025

39901286 (PubMed )
Supplement: 13036_2025_482_MOESM3_ESM.xlsx › table_for_paper

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants.

MacGowan SA et al.

Plos Computational Biology, 2022

35235558 (PubMed )
Supplement: pcbi.1009922.s001.xlsx › Sheet1

An overview of human proteins and genes involved in SARS-CoV-2 infection.

Jahanafrooz Z et al.

Gene, 2022

SARS-CoV-2 receptor-binding mutations and antibody contact sites.

Mejdani M et al.

Antibody Therapeutics, 2021

34386694 (PubMed )
Supplement: Supplementary_Table_3_-_Full_bioinformatics_analysis_tbab015.xlsx › Nucleotide_Mutant_Frequency

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Suryamohan K et al.

Communications Biology, 2021

33846513 (PubMed )
Supplement: 42003_2021_2030_MOESM1_ESM.pdf

Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.

Calcagnile M et al.

Biochimie, 2021

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).

Guo X et al.

Journal of Translational Medicine, 2020

32831104 (PubMed )
Supplement: 12967_2020_2486_MOESM1_ESM.xls › gnomAD_v2.1.1_ENSG00000130234_2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."