Varaico: Literature-Extracted Genetic Variants

Gene:ACE2
Variant:p.E37K
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ACE2

NM_001371415.1:p.E37K

Associated Papers

Impact of African-Specific ACE2 Polymorphisms on Omicron BA.4/5 RBD Binding and Allosteric Communication Within the ACE2-RBD Protein Complex.

Barozi V et al.

International Journal of Molecular Sciences, 2025

Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity.

Okal EF et al.

Journal of Biological Engineering, 2025

39901286 (PubMed )
Supplement: 13036_2025_482_MOESM3_ESM.xlsx › table_for_paper

Germline predisposition in multiple myeloma.

Martins Rodrigues F et al.

Iscience, 2025

39845416 (PubMed )
Supplement: mmc3.xlsx › ST2D.Vars_in_all_genes_MMRF

Polymorphisms in the human angiotensin converting enzyme gene (ACE) linked to susceptibility of COVID-19 and malaria infections in the Ghanaian population.

Duah-Quashie NO et al.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 2024

Entropic Overcompensation of the N501Y Mutation on SARS-CoV-2 S Binding to ACE2.

Vergara NG et al.

Journal of Chemical Information and Modeling, 2023

Intronic Variants of the Angiotensin-Converting Enzyme 2 Gene Modulate Plasma ACE2 Levels and Possibly Confer Protection against Severe COVID-19.

Ahmed R et al.

Biomed Research International, 2023

Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.

Talebi T et al.

Genetics Research, 2023

Structural Profiles of SARS-CoV-2 Variants in India.

Chakraborti S et al.

Current Microbiology, 2022

Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex.

Ortuso F et al.

Journal of Biomolecular Structure & Dynamics, 2022

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineages.

Tahsin A et al.

Computers in Biology and Medicine, 2022

Entropic overcompensation of the N501Y mutation on SARS-CoV-2 S binding to ACE2.

Vergara NG et al.

Biorxiv : the Preprint Server for Biology, 2022

The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature.

Ishak A et al.

Gene, 2022

Analysis of the docking property of host variants of hACE2 for SARS-CoV-2 in a large cohort.

Paik H et al.

Plos Computational Biology, 2022

Association of polymorphisms in tumor necrosis factors with SARS-CoV-2 infection and mortality rate: A case-control study and in silico analyses.

Heidari Nia M et al.

Journal of Medical Virology, 2022

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants.

MacGowan SA et al.

Plos Computational Biology, 2022

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review.

Li J et al.

European Journal of Medical Research, 2022

An overview of human proteins and genes involved in SARS-CoV-2 infection.

Jahanafrooz Z et al.

Gene, 2022

Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection.

Ren W et al.

Journal of Virology, 2022

Genetic variations affecting ACE2 protein stability in minority populations.

Mahase V et al.

Frontiers in Medicine, 2022

The role of angiotensin-converting enzyme 2 (ACE2) genetic variations in COVID-19 infection: a literature review.

Fawzy MS et al.

The Egyptian Journal of Medical Human Genetics, 2022

Spike residue 403 affects binding of coronavirus spikes to human ACE2.

Zech F et al.

Nature Communications, 2021

SARS-CoV-2 receptor-binding mutations and antibody contact sites.

Mejdani M et al.

Antibody Therapeutics, 2021

34386694 (PubMed )
Supplement: Supplementary_Table_3_-_Full_bioinformatics_analysis_tbab015.xlsx › Nucleotide_Mutant_Frequency

Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2.

Bhattacharjee MJ et al.

Molecular Biology and Evolution, 2021

Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.

Fujikura K et al.

Journal of Clinical Pathology, 2021

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Suryamohan K et al.

Communications Biology, 2021

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19.

Al-Mulla F et al.

Heliyon, 2021

COVID-19: The Effect of Host Genetic Variations on Host-Virus Interactions.

Chakravarty S

Journal of Proteome Research, 2021

Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.

Calcagnile M et al.

Biochimie, 2021

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.

Saih A et al.

Biomed Research International, 2021

Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators.

Zhang J et al.

Frontiers in Medicine, 2021

34458283 (PubMed )
Supplement: Table_1.XLS › ACE2

The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and Therapy.

Chen F et al.

Frontiers in Cellular and Infection Microbiology, 2021

Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design.

Sorokina M et al.

Scientific Data, 2020

Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?

Lippi G et al.

Clinical Chemistry and Laboratory Medicine, 2020

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).

Guo X et al.

Journal of Translational Medicine, 2020

32831104 (PubMed )
Supplement: 12967_2020_2486_MOESM1_ESM.xls › gnomAD_v2.1.1_ENSG00000130234_2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."