Associated Papers
PPAC: Predicting Protein-Protein Affinity Changes Induced by Amino Acid Mutations Using Protein Large Language Models.
Zhang L et al.
Acs Omega, 2025
Impact of African-Specific ACE2 Polymorphisms on Omicron BA.4/5 RBD Binding and Allosteric Communication Within the ACE2-RBD Protein Complex.
Barozi V et al.
International Journal of Molecular Sciences, 2025
Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics.
Waman VP et al.
Scientific Reports, 2024
Polymorphisms in the human angiotensin converting enzyme gene (ACE) linked to susceptibility of COVID-19 and malaria infections in the Ghanaian population.
Duah-Quashie NO et al.
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 2024
Serum ACE2 and S19P gene polymorphism in Egyptian patients with COVID-19 infection: correlation with disease severity.
Gaber DA et al.
Scientific Reports, 2024
Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients.
Elemam NM et al.
Frontiers in Immunology, 2024
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants.
Haycroft ER et al.
Medical Microbiology and Immunology, 2023
Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities.
Adimulam T et al.
International Journal of Molecular Sciences, 2023
Intronic Variants of the Angiotensin-Converting Enzyme 2 Gene Modulate Plasma ACE2 Levels and Possibly Confer Protection against Severe COVID-19.
Ahmed R et al.
Biomed Research International, 2023
Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.
Talebi T et al.
Genetics Research, 2023
Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation.
Rodriguez JA et al.
Chemico-biological Interactions, 2022
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking.
Badawi S et al.
Human Genomics, 2022
Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex.
Ortuso F et al.
Journal of Biomolecular Structure & Dynamics, 2022
Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19.
Ma Y et al.
Pathogens (basel, Switzerland), 2022
COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity.
David S et al.
Immunogenetics, 2022
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection.
Hu P et al.
Viruses, 2022
Association of polymorphisms in tumor necrosis factors with SARS-CoV-2 infection and mortality rate: A case-control study and in silico analyses.
Heidari Nia M et al.
Journal of Medical Virology, 2022
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants.
MacGowan SA et al.
Plos Computational Biology, 2022
Identification of destabilizing SNPs in SARS-CoV2-ACE2 protein and spike glycoprotein: implications for virus entry mechanisms.
Khalid Z et al.
Journal of Biomolecular Structure & Dynamics, 2022
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study.
Baştuğ S et al.
Anatolian Journal of Cardiology, 2022
An overview of human proteins and genes involved in SARS-CoV-2 infection.
Jahanafrooz Z et al.
Gene, 2022
Genetic variations affecting ACE2 protein stability in minority populations.
Mahase V et al.
Frontiers in Medicine, 2022
The role of angiotensin-converting enzyme 2 (ACE2) genetic variations in COVID-19 infection: a literature review.
Fawzy MS et al.
The Egyptian Journal of Medical Human Genetics, 2022
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.
Ye F et al.
Signal Transduction and Targeted Therapy, 2021
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics.
Barton MI et al.
Elife, 2021
Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2.
Bhattacharjee MJ et al.
Molecular Biology and Evolution, 2021
Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.
Fujikura K et al.
Journal of Clinical Pathology, 2021
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.
Suryamohan K et al.
Communications Biology, 2021
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19.
Choudhary S et al.
Annals of Laboratory Medicine, 2021
The impact of certain genetic variants (single nucleotide polymorphisms) on incidence and severity of COVID-19.
Abobaker A et al.
The Journal of Gene Medicine, 2021
Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro.
Hashizume M et al.
Viruses, 2021
COVID-19: The Effect of Host Genetic Variations on Host-Virus Interactions.
Chakravarty S
Journal of Proteome Research, 2021
Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.
Calcagnile M et al.
Biochimie, 2021
Genetic variability in COVID-19-related genes in the Brazilian population.
Secolin R et al.
Human Genome Variation, 2021
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.
Saih A et al.
Biomed Research International, 2021