Associated Papers
Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes.
Badonyi M et al.
Nature Communications, 2025
40998763 (PubMed )
Supplement: 41467_2025_63234_MOESM6_ESM.xlsx › Supplementary_Fig3a
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.
Masi M et al.
Cell Death Discovery, 2025
40091075 (PubMed )
Supplement: 41420_2025_2382_MOESM3_ESM.xlsx › BioGRID_ATM_-_jan24
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ et al.
Biorxiv : the Preprint Server for Biology, 2024
39484452 (PubMed )
Supplement: media-2.zip › Extended_Data_Tables › Extended_Data_Table_1.xlsx › KRAS_GOF_DMS_Screen
AI-Based Homology Modelling of Fatty Acid Transport Protein 1 Using AlphaFold: Structural Elucidation and Molecular Dynamics Exploration.
Acharya R et al.
Biomolecules, 2023
38002353 (PubMed )
Supplement: biomolecules-13-01670-s001.zip › biomolecules-2653978-supplementary.pdf
Pathogenicity Prediction of GABAA Receptor Missense Variants.
Wang YJ et al.
Biorxiv : the Preprint Server for Biology, 2023
38014242 (PubMed )
Supplement: media-4.xlsx › g2_CV-AM-RS
DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia.
Campolungo D et al.
Science Advances, 2023
37713484 (PubMed )
Supplement: sciadv.adi3771_tables_s1_to_s6.zip › adi3771_Table_S3.xlsx › 1_WT_DUX4_peaks
Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.
Willis JCW et al.
Nature Communications, 2022
36418298 (PubMed )
Supplement: 41467_2022_34784_MOESM3_ESM.xlsx › 8._DddA_point_mutations
In Silico Genome Analysis Reveals the Evolution and Potential Impact of SARS-CoV-2 Omicron Structural Changes on Host Immune Evasion and Antiviral Therapeutics.
Chauhan D et al.
Viruses, 2022
36366559 (PubMed )
Supplement: viruses-14-02461-s001.zip › Table_S5_10292022.xlsx › Unique_Structural_mutation_freq
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma.
Smith LK et al.
Nature Communications, 2022
35232962 (PubMed )
Supplement: 41467_2022_28705_MOESM5_ESM.xlsx › Lactate_0.5_FC_Hits
Genetic Diagnostic Yield and Novel Causal Genes of Congenital Heart Disease.
Tan M et al.
Frontiers in Genetics, 2022
35910219 (PubMed )
Supplement: DataSheet1.xlsx › Table_S7
DNA damage checkpoint activation affects peptidoglycan synthesis and late divisome components in Bacillus subtilis.
Masser EA et al.
Molecular Microbiology, 2021
Distinct genomic profile in h. pylori-associated gastric cancer.
Zhang X et al.
Cancer Medicine, 2021
33751865 (PubMed )
Supplement: CAM4-10-2461-s001.xlsx › somatic_muts.gastric_samples.le
The Association Between Lysosomal Storage Disorder Genes and Parkinson's Disease: A Large Cohort Study in Chinese Mainland Population.
Zhao YW et al.
Frontiers in Aging Neuroscience, 2021
34867278 (PubMed )
Supplement: Data_Sheet_1.PDF
High-throughput, microscope-based sorting to dissect cellular heterogeneity.
Hasle N et al.
Molecular Systems Biology, 2020
32500953 (PubMed )
Supplement: MSB-16-e9442-s008.xls › Dataset_EV1
Dysregulation of neuron differentiation in an autistic savant with exceptional memory.
Song J et al.
Molecular Brain, 2019
31699123 (PubMed )
Supplement: 13041_2019_507_MOESM1_ESM.xlsx › SNPs_merged_1000g_deleterious
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Chen H et al.
Nature Communications, 2019
31399586 (PubMed )
Supplement: 41467_2019_11551_MOESM4_ESM.xlsx › b
Isolation of Fission Yeast Condensin Temperature-Sensitive Mutants with Single Amino Acid Substitutions Targeted to Hinge Domain.
Xu X et al.
G3 (bethesda, Md.), 2019
Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients.
Deng Q et al.
Heliyon, 2018
30603682 (PubMed )
Supplement: mmc2.xlsx › Raw_reads_info
Behavior-dependent cis regulation reveals genes and pathways associated with bower building in cichlid fishes.
York RA et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
30397142 (PubMed )
Supplement: pnas.1810140115.sd01.xlsx › Gene_Set
Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.
Oliveira DM et al.
Oncotarget, 2018
29844865 (PubMed )
Supplement: oncotarget-09-23960-s003.xlsx › Supplemental_Table_S2
NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells.
Wu TH et al.
Plos One, 2018
29590119 (PubMed )
Supplement: pone.0193126.s001.xlsx › NF90_NF110_intergenic
Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer.
Goetz MP et al.
Journal of the National Cancer Institute, 2017
28376176 (PubMed )
Supplement: djw306_Supp.zip › 16-0785R2_Goetz_Supplementary_Tables_3-6_111716.xlsx › Suppl_Table_5e
The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.
Lim CH et al.
Oncotarget, 2016
27175599 (PubMed )
Supplement: oncotarget-07-39758-s005.xlsx › TableS4
Joint mouse-human phenome-wide association to test gene function and disease risk.
Wang X et al.
Nature Communications, 2016
26833085 (PubMed )
Supplement: ncomms10464-s5.xlsx › Supplementary_Data_4
Cooperation between Noncanonical Ras Network Mutations.
Stites EC et al.
Cell Reports, 2015
25600866 (PubMed )
Supplement: 1-s2.0-S221112471401064X-mmc2.xlsx › Sheet1
Mutational analysis of primary central nervous system lymphoma.
Bruno A et al.
Oncotarget, 2014
24970810 (PubMed )
Supplement: oncotarget-05-5065-s001.xls › Table_S1
Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing.
Bhadury J et al.
Oncogenesis, 2013
23588493 (PubMed )
Supplement: oncsis20138x8.xls › Colon_26_SNPs
Systematic generation of in vivo G protein-coupled receptor mutants in the rat.
van Boxtel R et al.
The Pharmacogenomics Journal, 2011
20531371 (PubMed )
Supplement: tpj201044x3.xls › Mutations
In silico prediction of deleterious single amino acid polymorphisms from amino acid sequence.
Li S et al.
Journal of Computational Chemistry, 2011
21425278 (PubMed )
Supplement: supplement_1.pdf
MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component.
Zhou H et al.
Journal of Bacteriology, 2005
Genetic identification of two functional regions in the antitoxin of the parD killer system of plasmid R1.
Santos-Sierra S et al.
Fems Microbiology Letters, 2002
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