Varaico: Literature-Extracted Genetic Variants

Gene:ADAM17
Variant:p.M435I
Back to variants list

ADAM17

NM_003183.6:p.M435I

Associated Papers

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain.

Dobert JP et al.

Biomedicines, 2020

Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding.

Li X et al.

World Journal of Biological Chemistry, 2011

The transmembrane domain of TACE regulates protein ectodomain shedding.

Li X et al.

Cell Research, 2007

Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity.

Pérez L et al.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 2007

Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE).

Li X et al.

The Journal of Biological Chemistry, 2004

Select a paper to view details
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."