Associated Papers
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex.
Maciag JJ et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease.
Hartl D et al.
Molecular Psychiatry, 2020
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
Wong E et al.
The Journal of Biological Chemistry, 2015
Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE).
Li X et al.
The Journal of Biological Chemistry, 2004
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