Associated Papers
Microgliosis and aberrant interferon response in Adar Mavs brain are rescued by PKR removal.
Lacovich V et al.
Brain : a Journal of Neurology, 2026
Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing.
Nichols PJ et al.
Biorxiv : the Preprint Server for Biology, 2025
A-to-I-Edited miR-1304-3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling.
Chen P et al.
Molecular Carcinogenesis, 2025
ADAR1: from basic mechanisms to inhibitors.
Rehwinkel J et al.
Trends in Cell Biology, 2025
Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells.
Yoshida A et al.
Frontiers in Genetics, 2025
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.
Fan B et al.
Nucleic Acids Research, 2024
ADAR1 promotes cisplatin resistance in intrahepatic cholangiocarcinoma by regulating BRCA2 expression through A-to-I editing manner.
Liu Q et al.
Cell Proliferation, 2024
ADARp150 counteracts whole genome duplication.
van Gemert F et al.
Nucleic Acids Research, 2024
Novel insights into double-stranded RNA-mediated immunopathology.
de Reuver R et al.
Nature Reviews. Immunology, 2024
Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC.
Luo J et al.
Hepatology (baltimore, Md.), 2024
ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Zhang B et al.
Nucleic Acids Research, 2023
Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1.
Rai R et al.
Nature Communications, 2023
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib.
Crews LA et al.
Cell Stem Cell, 2023
Recent Advances in Adenosine-to-Inosine RNA Editing in Cancer.
Gan WL et al.
Cancer Treatment and Research, 2023
ADAR1 and its implications in cancer development and treatment.
Baker AR et al.
Trends in Genetics : Tig, 2022
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels.
Hao X et al.
Nature Cell Biology, 2022
RNA editing underlies genetic risk of common inflammatory diseases.
Li Q et al.
Nature, 2022
ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance.
Jiang L et al.
The Journal of Clinical Investigation, 2022
ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian Cancer.
Cui H et al.
Journal of Cancer, 2022
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.
Shiromoto Y et al.
Nature Communications, 2021
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Kung CP et al.
Oncogene, 2021
High-throughput mutagenesis reveals unique structural features of human ADAR1.
Park S et al.
Nature Communications, 2020
Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation.
Jiang Q et al.
Cancer Cell, 2019
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.
Gannon HS et al.
Nature Communications, 2018
Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation.
Chen YT et al.
The Journal of Biological Chemistry, 2018
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.
Chung H et al.
Cell, 2018
ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay.
Sakurai M et al.
Nature Structural & Molecular Biology, 2017
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.
Liddicoat BJ et al.
Experimental Hematology, 2016
ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.
Chan TH et al.
Gastroenterology, 2016
A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1.
Wang Y et al.
Acs Chemical Biology, 2015
Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways.
Bahn JH et al.
Nature Communications, 2015
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Mannion NM et al.
Cell Reports, 2014
Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules.
Ng SK et al.
Nucleic Acids Research, 2013
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.
Nemlich Y et al.
The Journal of Clinical Investigation, 2013
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.
Rice GI et al.
Nature Genetics, 2012
Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.
Singh M et al.
The Journal of Biological Chemistry, 2007
Two novel mutations and evidence for haploinsufficiency of the ADAR gene in dyschromatosis symmetrica hereditaria.
Liu Q et al.
The British Journal of Dermatology, 2006
ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.
Yang W et al.
The Journal of Biological Chemistry, 2005
Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.
Cho DS et al.
The Journal of Biological Chemistry, 2003
Editing of glutamate receptor subunit B pre-mRNA by splice-site variants of interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1.
Liu Y et al.
The Journal of Biological Chemistry, 1999
Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.
Liu Y et al.
Journal of Virology, 1996