Varaico: Literature-Extracted Genetic Variants

Gene:ADIPOQ
Variant:p.R221S
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ADIPOQ

NM_004797.4:p.R221S

Associated Papers

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.

Spracklen CN et al.

Plos Genetics, 2020

32915782 (PubMed )
Supplement: pgen.1009019.s022.xlsx › S4_Table

Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.

Gao H et al.

Diabetes, 2013

Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.

Warren LL et al.

Diabetes, 2012

22403302 (PubMed )
Supplement: supp_db11-0985_DB110985SupplementaryData.pdf

Population-specific coding variant underlies genome-wide association with adiponectin level.

Croteau-Chonka DC et al.

Human Molecular Genetics, 2012

Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects.

Jungtrakoon P et al.

Plos One, 2011

Adiponectin gene polymorphisms are associated with long-chain ω3-polyunsaturated fatty acids in serum phospholipids in nondiabetic Koreans.

Kim B et al.

The Journal of Clinical Endocrinology and Metabolism, 2010

Association of adipose most abundant transcript 1 gene (apM1) with type 2 diabetes mellitus in a Chinese population: a meta-analysis of case-control studies.

Li S et al.

Clinical Endocrinology, 2008

The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.

Jang Y et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2008

Molecular analysis of the adiponectin gene in severely obese patients from southern Italy.

Daniele A et al.

Annals of Nutrition & Metabolism, 2008

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss.

Shin MJ et al.

International Journal of Obesity (2005), 2006

Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.

Heid IM et al.

Diabetes, 2006

The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin.

Jang Y et al.

Metabolism: Clinical and Experimental, 2006

Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans.

Jang Y et al.

The American Journal of Clinical Nutrition, 2005

Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.

Ohashi K et al.

Journal of the American College of Cardiology, 2004

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

Waki H et al.

The Journal of Biological Chemistry, 2003

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

Vasseur F et al.

Human Molecular Genetics, 2002

Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.

Kondo H et al.

Diabetes, 2002

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

Hara K et al.

Diabetes, 2002

Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians.

Vendramini MF et al.

Journal of Diabetes and Its Complications, 0

In silico Evaluation of Nonsynonymous Single Nucleotide Polymorphisms in the ADIPOQ Gene Associated with Diabetes, Obesity, and Inflammation.

Narayana Swamy A et al.

Avicenna Journal of Medical Biotechnology, 0

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