Varaico: Literature-Extracted Genetic Variants

Gene:AGR2
Variant:p.C81S
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AGR2

NM_006408.4:p.C81S

Associated Papers

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.

Neidhardt L et al.

The Embo Journal, 2024

AGR2-AGR3 hetero-oligomeric complexes: Identification and characterization.

Černocká H et al.

Bioelectrochemistry (amsterdam, Netherlands), 2021

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

Tiemann K et al.

Oncogene, 2019

Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties.

Fessart D et al.

Elife, 2016

Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.

Patel P et al.

Journal of Molecular Biology, 2013

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

Park SW et al.

Proceedings of the National Academy of Sciences of the United States of America, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."