Associated Papers
Ile258Met mutation of Brucella melitensis 7α-hydroxysteroid dehydrogenase significantly enhances catalytic efficiency, cofactor affinity, and thermostability.
Liu Z et al.
Applied Microbiology and Biotechnology, 2021
Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.
El-Kabbani O et al.
Bioorganic & Medicinal Chemistry Letters, 2011
Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.
El-Kabbani O et al.
European Journal of Medicinal Chemistry, 2010
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.
Dhagat U et al.
Bioorganic & Medicinal Chemistry Letters, 2010
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