Varaico: Literature-Extracted Genetic Variants

Gene:AKT1
Variant:p.E464K
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AKT1

NM_001382430.1:p.E464K

Associated Papers

Efficacy of ATR Kinase Inhibitor Elimusertib Monotherapy or Combination in Tumors with DNA Damage Response Pathway and Other Genomic Alterations.

Varadarajan K et al.

Molecular Cancer Therapeutics, 2025

40300249 (PubMed )
Supplement: mct-24-0884_supplementary_table_2_suppst2.pdf

Genomic alteration discordance in the paired primary-recurrent ovarian cancers: based on the comprehensive genomic profiling (CGP) analysis.

Dong J et al.

Journal of Ovarian Research, 2024

38937827 (PubMed )
Supplement: 13048_2024_1455_MOESM7_ESM.xlsx › Table_S2

Discovering Deleterious Single Nucleotide Polymorphisms of Human AKT1 Oncogene: An In Silico Study.

Zhang R et al.

Life (basel, Switzerland), 2023

37511907 (PubMed )
Supplement: life-13-01532-s001.zip › Supplementary_Table_S2.pdf

Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

He P et al.

Frontiers in Oncology, 2023

36910641 (PubMed )
Supplement: DataSheet_1.xlsx › Table_S8

AKT mutant allele-specific activation dictates pharmacologic sensitivities.

Shrestha Bhattarai T et al.

Nature Communications, 2022

Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.

McAuliffe PF et al.

Plos One, 2015

26325287 (PubMed )
Supplement: pone.0136851.s006.xlsx › 006
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