Associated Papers
AKT1E17K-Interacting lncRNA SVIL-AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation.
Wang J et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
Delivery of AKT1 phospho-forms to human cells reveals differential substrate selectivity.
Siddika T et al.
Iubmb Life, 2024
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1.
Un Nisa M et al.
Journal of Cell Communication and Signaling, 2023
Clinicopathological and molecular characteristics of patients with hypermutant lung cancer: A retrospective cohort study.
Zhang H et al.
Oncology Letters, 2021
Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation.
Gaviraghi M et al.
Scientific Reports, 2020
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Mao H et al.
Protein & Cell, 2019
Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191.
Ni H et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2018
Functional characterization of lysosomal interaction of Akt with VRK2.
Hirata N et al.
Oncogene, 2018
Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells.
Szymonowicz K et al.
International Journal of Molecular Sciences, 2018
Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.
Balasuriya N et al.
The Journal of Biological Chemistry, 2018
Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation.
Youn HS et al.
Scientific Reports, 2017
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes.
Ebner M et al.
Molecular Cell, 2017
Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.
Risso G et al.
Cell Cycle (georgetown, Tex.), 2013
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
Zeng L et al.
Cancer Research, 2013
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
Ji H et al.
Embo Reports, 2012
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
Bailey-Downs LC et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2012
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Joung SM et al.
Journal of Immunology (baltimore, Md. : 1950), 2011
Akt2/PKBbeta-sensitive regulation of renal phosphate transport.
Kempe DS et al.
Acta Physiologica (oxford, England), 2010
Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.
Rodríguez-Escudero I et al.
The Journal of Biological Chemistry, 2009
Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes.
Goren I et al.
Biochemical and Biophysical Research Communications, 2008
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation.
Ananthanarayanan B et al.
The Journal of Biological Chemistry, 2007
Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells.
Xuan Nguyen TL et al.
Biochemical and Biophysical Research Communications, 2006
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation.
Song K et al.
The Embo Journal, 2006
Akt1 contains a functional leucine-rich nuclear export sequence.
Saji M et al.
Biochemical and Biophysical Research Communications, 2005
Serum and glucocorticoid inducible kinases functionally regulate ClC-2 channels.
Palmada M et al.
Biochemical and Biophysical Research Communications, 2004
Characterization of TCR-induced phosphorylation of PKCtheta in primary murine lymphocytes.
Thebault S et al.
Molecular Immunology, 2004
Vanadate activated Akt and promoted S phase entry.
Zhang Z et al.
Molecular and Cellular Biochemistry, 2004
Interleukin-1-receptor-associated kinase 2 (IRAK2)-mediated interleukin-1-dependent nuclear factor kappaB transactivation in Saos2 cells requires the Akt/protein kinase B kinase.
Cenni V et al.
The Biochemical Journal, 2003
Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
Zhang J et al.
Oncogene, 2003
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
Fujita N et al.
The Journal of Biological Chemistry, 2002
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Manning BD et al.
Molecular Cell, 2002
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site.
Toker A et al.
The Journal of Biological Chemistry, 2000
Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation.
Taha C et al.
The Journal of Biological Chemistry, 1999
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.
Sable CL et al.
The Journal of Biological Chemistry, 1998
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Bellacosa A et al.
Oncogene, 1998