Varaico: Literature-Extracted Genetic Variants

Gene:AKT1
Variant:p.Q61K
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AKT1

NM_001382430.1:p.Q61K

Associated Papers

Malignant adenomyoepithelioma with HRAS G13R mutation: A case report.

Kuwabara H et al.

Oncology Letters, 2026

Oral Melanocytic Neoplasms: A Narrative Review.

Maldonado-Mendoza J

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2025

The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling.

Lehman SS et al.

Cell Reports, 2024

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations.

Joshi A et al.

Oncotarget, 2021

RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients.

Malapelle U et al.

European Journal of Cancer (oxford, England : 1990), 2021

The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA.

Chang WJ et al.

Journal of Clinical Medicine, 2020

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.

Choi JY et al.

Cancer Research and Treatment, 2020

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Bandoh N et al.

Oncology Letters, 2018

Metastases risk in thin cutaneous melanoma: prognostic value of clinical-pathologic characteristics and mutation profile.

Richetta AG et al.

Oncotarget, 2018

Mutation analysis of the EGFR pathway genes, EGFR, RAS, PIK3CA, BRAF, and AKT1, in salivary gland adenoid cystic carcinoma.

Saida K et al.

Oncotarget, 2018

29682203 (PubMed )
Supplement: oncotarget-09-17043-s001.pdf

Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas.

Shimura T et al.

Oncotarget, 2018

29416736 (PubMed )
Supplement: oncotarget-09-1852-s001.pdf

Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients.

Chen Q et al.

Oncotargets and Therapy, 2018

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making.

Abida W et al.

Jco Precision Oncology, 2017

Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.

Gong J et al.

Oncotarget, 2017

Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.

Malapelle U et al.

Journal of Clinical Pathology, 2016

26797410 (PubMed )
Supplement: jclinpath-2015-203403-s2.pdf

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients.

Hsu HC et al.

Oncotarget, 2016

26989027 (PubMed )
Supplement: oncotarget-07-22257-s001.pdf

Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care.

Rennert H et al.

Npj Genomic Medicine, 2016

28781886 (PubMed )
Supplement: npjgenmed201619-s1.doc

RAS proto-oncogene in medullary thyroid carcinoma.

Moura MM et al.

Endocrine-related Cancer, 2015

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.

Ciampi R et al.

Thyroid : Official Journal of the American Thyroid Association, 2013

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf

Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma.

Santarpia L et al.

Cancer, 2010

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

Giovannetti E et al.

Molecular Cancer Therapeutics, 2010

Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations.

Niimi H et al.

Leukemia, 2006

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF.

Emuss V et al.

Cancer Research, 2005

A comprehensive procedural approach to genotyping KRAS and BRAF from paraffin embedded tissues for diagnostic purposes.

Palmirotta R et al.

In Vivo (athens, Greece), 0

Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Portet S et al.

Neuro-oncology Advances, 0

32642646 (PubMed )
Supplement: vdz003_suppl_supplementary_table_1.xlsx › Feuil1
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