Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Discovering Deleterious Single Nucleotide Polymorphisms of Human AKT1 Oncogene: An In Silico Study.
Zhang R et al.
Life (basel, Switzerland), 2023
Prevalence of Molecular Alterations in a Swiss Cohort of 512 Colorectal Carcinoma Patients by Targeted Next-Generation Sequencing Analysis in Routine Diagnostics.
Haefliger S et al.
Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2023
Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients.
Khatoon F et al.
3 Biotech, 2022
A p53-phosphoinositide signalosome regulates nuclear AKT activation.
Chen M et al.
Nature Cell Biology, 2022
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.
Yin S et al.
Nature Communications, 2021
Rare Germline Variants in Chordoma-Related Genes and Chordoma Susceptibility.
Yepes S et al.
Cancers, 2021
Higher Mutation Burden in High Proliferation Compartments of Heterogeneous Melanoma Tumors.
Grzywa TM et al.
International Journal of Molecular Sciences, 2021
Negative hyper-selection of metastatic colorectal cancer patients for anti-EGFR monoclonal antibodies: the PRESSING case-control study.
Cremolini C et al.
Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2017
Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity.
Oeck S et al.
Scientific Reports, 2017
Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis.
Harvey NT et al.
Pathology, 2016
PH motifs in PAR1&2 endow breast cancer growth.
Kancharla A et al.
Nature Communications, 2015
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
Orloff MS et al.
American Journal of Human Genetics, 2013
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Mahajan K et al.
Plos One, 2010
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Carpten JD et al.
Nature, 2007
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.
Stoica GE et al.
Oncogene, 2003
Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
Freeburn RW et al.
Journal of Immunology (baltimore, Md. : 1950), 2002
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.
Saito K et al.
The Journal of Biological Chemistry, 2001
Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.
Filippa N et al.
Molecular and Cellular Biology, 2000
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.
Sable CL et al.
The Journal of Biological Chemistry, 1998
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Bellacosa A et al.
Oncogene, 1998
Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane.
Yagisawa H et al.
The Journal of Biological Chemistry, 1998
AKT1 and AKT2 mutations in lung cancer in a Japanese population.
Sasaki H et al.
Molecular Medicine Reports, 0
Delayed MRI Enhancement of Colorectal Cancer Liver Metastases Is Associated With Metastatic Mutational Profile.
Seth A et al.
Cancer Genomics & Proteomics, 0