Varaico: Literature-Extracted Genetic Variants

Gene:AKT3
Variant:p.G171R
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AKT3

NM_005465.7:p.G171R

Associated Papers

Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression.

Gagoski D et al.

Protein Science : a Publication of the Protein Society, 2025

41088778 (PubMed )
Supplement: PRO-34-e70317-s008.xlsx › _S6_-_PTMVar_-_Fyn

Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression.

Gagoski D et al.

Biorxiv : the Preprint Server for Biology, 2025

39764007 (PubMed )
Supplement: media-1.xlsx › _S6_-_PTMVar_-_Fyn

Longitudinal analysis of treatment-induced genomic alterations in gliomas.

Erson-Omay EZ et al.

Genome Medicine, 2017

28153049 (PubMed )
Supplement: 13073_2017_401_MOESM3_ESM.xlsx › AllMutations_Clonality

AKT in cancer: new molecular insights and advances in drug development.

Mundi PS et al.

British Journal of Clinical Pharmacology, 2016

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology.

Ibarrola-Villava M et al.

Oncotarget, 2016

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

Kopetz S et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2015

26460303 (PubMed )
Supplement: supp_33.34.4032_DS_2015.632497.pdf

Germline activating AKT3 mutation associated with megalencephaly, polymicrogyria, epilepsy and hypoglycemia.

Nellist M et al.

Molecular Genetics and Metabolism, 2015

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

23633454 (PubMed )
Supplement: 10780432ccr130163-sup-tab1-3.pdf

Proteome-wide analysis of amino acid variations that influence protein lysine acetylation.

Suo SB et al.

Journal of Proteome Research, 2013

23298314 (PubMed )
Supplement: pr301007j_si_005.pdf

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.

Parikh C et al.

Proceedings of the National Academy of Sciences of the United States of America, 2012

Somatic activation of AKT3 causes hemispheric developmental brain malformations.

Poduri A et al.

Neuron, 2012

Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece.

Sozopoulos E et al.

Endocrine Pathology, 2010

PTEN signaling in brain: neuropathology and tumorigenesis.

Endersby R et al.

Oncogene, 2008

PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.

Kachrilas S et al.

Journal of B.u.on. : Official Journal of the Balkan Union of Oncology, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."