Associated Papers
ALDH2 variants - a role in cardiometabolic syndrome.
Jia G et al.
Metabolism: Clinical and Experimental, 2026
E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.
Han T et al.
Jci Insight, 2026
ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
Janesha UGS et al.
Cellular and Molecular Life Sciences : Cmls, 2026
ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.
Chen YC et al.
Life Sciences, 2026
The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis.
Sun S et al.
Circulation, 2026
Aldehyde dehydrogenase 2 mitigates acrolein-driven ferroptosis to preserve kidney function.
Kuo YM et al.
Environmental Pollution (barking, Essex : 1987), 2026
ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.
Chen X et al.
Circulation, 2026
Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions.
Lózsa R et al.
Communications Biology, 2026
ALDH2 rs671 Variant Lowers Blood Pressure Via the Endothelial HSPA5-PIEZO1-eNOS Pathway.
Ye H et al.
Journal of the American Heart Association, 2026
Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan.
Sung YF et al.
Alcohol, Clinical & Experimental Research, 2026
Correlation Between ALDH2 Gene Polymorphism and Coronary Artery Disease in Patients With Atrial Fibrillation.
Zheng B et al.
Cardiovascular Therapeutics, 2026
Evidence for early endothelial dysfunction associated with the ALDH2 rs671 gene variant: A preliminary investigation with young East Asians.
Lioy B et al.
Experimental Physiology, 2025
Identification of a Novel FLNC Truncating Variant in Fetal Tetralogy of Fallot: A Case Report and Review of the Literature.
Zhang Z et al.
Diagnostics (basel, Switzerland), 2025
Genetic Determinants of Leisure-Time Physical Activity in the Taiwanese Population: A Genome-Wide Association Study.
Hsu LA et al.
Medicine and Science in Sports and Exercise, 2025
Genetic and epigenetic determinants of fetal alcohol spectrum disorders: Toward a precision medicine approach.
Sessa F et al.
Experimental and Molecular Pathology, 2025
Low Alanine Aminotransferase Levels in Alcohol Consuming Male Subjects, Carriers of the Common ALDH2 Deficient Variant, ALDH2*2.
Seike T et al.
Hepatology Research : the Official Journal of the Japan Society of Hepatology, 2025
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.
Enzan N et al.
Nature Communications, 2025
Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients.
Matsui H et al.
Head & Neck, 2025
A case of ADH5/ALDH2 deficiency combined with 3q29 microduplication syndrome.
Chenzhuo S et al.
Bmc Pediatrics, 2025
ALDH2 Deficiency Drives Proliferative Mammary Morphogenesis and Epithelial Cell Stemness via Oxidative Stress and Estrogen Receptor Activation.
Ma Z et al.
Biorxiv : the Preprint Server for Biology, 2025
ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases.
Duan Y et al.
Military Medical Research, 2025
Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.
Vujkovic M et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.
Zhang H et al.
Cell Reports. Medicine, 2025
Estimating genetic load from 5000 Chinese exomes.
Du X et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
Genetic Polymorphisms of ALDH2 and ADH1B in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations.
Tadokoro T et al.
International Journal of Molecular Sciences, 2025
Targeting ALDH2 to promote skeletal muscle health: A novel strategy against mitochondrial dysfunction.
Andrade KSG et al.
The Journal of Physiology, 2025
Corrigendum: Novel and prevalent non-East Asian ALDH2 variants; implications for global susceptibility to aldehydes' toxicity EBioMedicine (2020) - doi: 10.1016/j.ebiom.2020.102753.
Chen CH et al.
Ebiomedicine, 2025
ALDH2 Enzyme Deficiency in Diabetic Cardiomyopathy.
Hsieh YW et al.
International Journal of Molecular Sciences, 2025
Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population.
Chen X et al.
Journal of Stroke, 2025
Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis.
Yamamoto S et al.
Carcinogenesis, 2025
The combined effect between environmental exposure and oxidative stress-related susceptible gene polymorphisms on human semen quality.
Wu S et al.
Journal of Assisted Reproduction and Genetics, 2025
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability.
Urano T et al.
Human Cell, 2025
Cord Blood Transplantation Using Myeloablative Conditioning for Pediatric Advanced Myelodysplastic Syndrome in AMeD Syndrome With a Novel ADH5 Variant.
Morishita Y et al.
Pediatric Blood & Cancer, 2025
Genetic Polymorphism in Alcohol Metabolism and Drinking Behavior Are Associated with Gastric Cancer Risk in Men.
Asanuma K et al.
Internal Medicine (tokyo, Japan), 2025
Suppression of aldehyde dehydrogenase 2 in kidney proximal tubules contributes to kidney fibrosis through Transforming Growth Factor-β signaling.
Chiu IJ et al.
Kidney International, 2025
Understanding the link between ALDH2 genotypes and diabetes.
Peng M et al.
Frontiers in Endocrinology, 2025
Geographical distribution of ALDH2 rs671 polymorphism in Chinese angina pectoris patients.
Dong W et al.
Frontiers in Genetics, 2025
Association between ALDH2 rs671 polymorphism and susceptibility to non-valvular atrial fibrillation in a Chinese population: a large-scale case-control study.
Zhong F et al.
Frontiers in Physiology, 2025
Synthetic mismatches enable specific CRISPR-Cas12a-based detection of genome-wide SNVs tracked by ARTEMIS.
Kohabir KAV et al.
Cell Reports Methods, 2024
Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma.
Shan G et al.
Free Radical Biology & Medicine, 2024
A genome-wide association analysis reveals new pathogenic pathways in gout.
Major TJ et al.
Nature Genetics, 2024
Aldehyde dehydrogenase 2 preserves kidney function by countering acrolein-induced metabolic and mitochondrial dysfunction.
Li SY et al.
Jci Insight, 2024
ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages.
Rui H et al.
Redox Biology, 2024
Population-specific putative causal variants shape quantitative traits.
Koyama S et al.
Nature Genetics, 2024
Asian Flush Gene Variant Enhances Cellular Immunogenicity of COVID-19 Vaccine: Prospective Observation in the Japanese General Population.
Bogahawaththa S et al.
Vaccines, 2024
Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations.
Lim J et al.
International Journal of Stem Cells, 2024
Human genetics and epigenetics of alcohol use disorder.
Zhou H et al.
The Journal of Clinical Investigation, 2024
Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging.
Rieckher M et al.
Nucleic Acids Research, 2024