Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.D1270N
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ALK

NM_004304.5:p.D1270N

Associated Papers

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity.

Lucken K et al.

Molecular Cancer Research : Mcr, 2022

Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.

Sampson J et al.

Embo Reports, 2021

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.

O'Regan L et al.

Journal of Cell Science, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."