Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.R1212H
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ALK

NM_004304.5:p.R1212H

Associated Papers

Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C-mutated advanced non-small cell lung cancer.

Passiglia F et al.

Cancer, 2025

40445863 (PubMed )
Supplement: CNCR-131-e35917-s003.xlsx › Foglio1

An in silico evaluation of lorlatinib as a potential therapy for novel amino acid substitutions in the tyrosine kinase domain of the ALK protein associated with cancer.

Zapata Dongo RJ et al.

Frontiers in Pharmacology, 2025

Tumor organoids improve mutation detection of pancreatic ductal adenocarcinoma.

Farshadi EA et al.

Scientific Reports, 2024

39462012 (PubMed )
Supplement: 41598_2024_75888_MOESM2_ESM.xlsx › Figure2

The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms.

Liu M et al.

The Oncologist, 2023

37086484 (PubMed )
Supplement: oyad093_suppl_supplementary_table_1.xlsx › Genetic_Variations

SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation.

Costa D et al.

Cells, 2023

36831331 (PubMed )
Supplement: cells-12-00664-s001.zip › Table_S2__Cells_.xlsx › Suppl_Table2

TP53 mutation and MET amplification in circulating tumor DNA analysis predict disease progression in patients with advanced gastric cancer.

Li J et al.

Peerj, 2021

33959414 (PubMed )
Supplement: peerj-09-11146-s003.xlsx › Sheet2

Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic.

Williams EA et al.

Acta Neuropathologica Communications, 2020

33087175 (PubMed )
Supplement: 40478_2020_1040_MOESM1_ESM.xlsx › Sheet1

Genotyping of Circulating Tumor DNA Reveals the Clinically Actionable Mutation Landscape of Advanced Colorectal Cancer.

Cao W et al.

Molecular Cancer Therapeutics, 2019

31015309 (PubMed )
Supplement: 15357163mct181247-sup-211489_2_supp_5355372_pn7d76.pdf

Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.

Johnson A et al.

The Oncologist, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."