Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.S1206A
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ALK

NM_004304.5:p.S1206A

Associated Papers

Activity of Brigatinib in Patients With Crizotinib-Resistant ALK-positive Non-Small-Cell Lung Cancer According to ALK Fusion and Mutation Status.

Bazhenova L et al.

Clinical Lung Cancer, 2025

Presence of On-Target Resistant Mutation in Pre-Treatment Samples of ALK Fusion Gene Positive Lung Cancer Patients.

Li W et al.

Cancers, 2025

Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report.

Saw SPL et al.

Jto Clinical and Research Reports, 2023

Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer.

Shiba-Ishii A et al.

Nature Cancer, 2022

Mutation-tailored treatment selection in non-small cell lung cancer patients in daily clinical practice.

Steeghs EMP et al.

Lung Cancer (amsterdam, Netherlands), 2022

Genomic profiles of Indonesian colorectal cancer patients.

Abdullah M et al.

F1000research, 2022

Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies.

Christopoulos P et al.

Translational Lung Cancer Research, 2021

34164264 (PubMed )
Supplement: tlcr-10-05-2118-supplementary.pdf

Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA.

Dietz S et al.

Ebiomedicine, 2020

33161228 (PubMed )
Supplement: mmc1.pdf

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.

Zhang S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."