Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.L1198P
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ALK

NM_004304.5:p.L1198P

Associated Papers

Mutational profiling using liquid biopsy to guide targeted therapy in patients with metastatic cancer.

Mazouji O et al.

Scientific Reports, 2025

New pan-ALK inhibitor-resistant EML4::ALK mutations detected by liquid biopsy in lung cancer patients.

Villa M et al.

Npj Precision Oncology, 2024

The landscape of actionable genomic alterations in lung adenocarcinomas in India.

Sharma R et al.

Frontiers in Genetics, 2023

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

Diagnosis and Treatment of ALK Aberrations in Metastatic NSCLC.

Friedlaender A et al.

Current Treatment Options in Oncology, 2019

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.

Lindeman NI et al.

Archives of Pathology & Laboratory Medicine, 2018

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.

Lindeman NI et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

Negative hyper-selection of metastatic colorectal cancer patients for anti-EGFR monoclonal antibodies: the PRESSING case-control study.

Cremolini C et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2017

Insight into drug resistance mechanisms and discovery of potential inhibitors against wild-type and L1196M mutant ALK from FDA-approved drugs.

Li J et al.

Journal of Molecular Modeling, 2016

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Lindeman NI et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2013

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Lindeman NI et al.

Archives of Pathology & Laboratory Medicine, 2013

ALK-mutated non-small-cell lung cancer: a new strategy for cancer treatment.

Cabezón-Gutiérrez L et al.

Lung, 2012

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

Heuckmann JM et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."