Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.I1170S
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ALK

NM_004304.5:p.I1170S

Associated Papers

Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.

George SL et al.

Cancer Discovery, 2025

39693475 (PubMed )
Supplement: cd-24-0916_supplementary_table_2_suppst2.xlsx › Sheet1

Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis.

Ek T et al.

Cancer Research Communications, 2024

39177282 (PubMed )
Supplement: crc-24-0338_supplementary_information_suppsi.docx

Benefits for children with suspected cancer from routine whole-genome sequencing.

Hodder A et al.

Nature Medicine, 2024

Genomic ALK alterations in primary and relapsed neuroblastoma.

Rosswog C et al.

British Journal of Cancer, 2023

36807339 (PubMed )
Supplement: 41416_2023_2208_MOESM1_ESM.pdf

Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing.

Szymansky A et al.

Journal of Personalized Medicine, 2021

34442335 (PubMed )
Supplement: jpm-11-00691-s001.zip › S15-SNVs_routine_cohort.xlsx › SNVs_Bigcohort

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Patil K et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

Computational algorithms for in silico profiling of activating mutations in cancer.

Jordan EJ et al.

Cellular and Molecular Life Sciences : Cmls, 2019

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.

Lambertz I et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2015

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.

Bresler SC et al.

Cancer Cell, 2014

High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma.

Schulte JH et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients.

Passoni L et al.

Cancer Research, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."