Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.I1170N
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ALK

NM_004304.5:p.I1170N

Associated Papers

Detection of Targetable Genetic Abnormalities in Neuroblastoma Circulating Tumour DNA.

Danilenko M et al.

International Journal of Molecular Sciences, 2025

Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis.

Ek T et al.

Cancer Research Communications, 2024

39177282 (PubMed )
Supplement: crc-24-0338_supplementary_information_suppsi.docx

Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving ALK-Targeted Therapy.

Bobin C et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed ALK F1174L-mutated neuroblastoma.

Liu T et al.

Cold Spring Harbor Molecular Case Studies, 2021

Crizotinib response in a neuroblastoma patient with a constitutional mosaic anaplastic lymphoma kinase I1170N-activating mutation.

Harvey M et al.

Pediatric Blood & Cancer, 2021

Landscape of drug-resistance mutations in kinase regulatory hotspots.

Kim P et al.

Briefings in Bioinformatics, 2021

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Patil K et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

Computational algorithms for in silico profiling of activating mutations in cancer.

Jordan EJ et al.

Cellular and Molecular Life Sciences : Cmls, 2019

Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies.

Mossé YP

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.

Bresler SC et al.

Cancer Cell, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."