Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.E1129V
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ALK

NM_004304.5:p.E1129V

Associated Papers

Anaplastic lymphoma kinase inhibitors-a review of anticancer properties, clinical efficacy, and resistance mechanisms.

Kiełbowski K et al.

Frontiers in Pharmacology, 2023

A computational examination of the therapeutic advantages of fourth-generation ALK inhibitors TPX-0131 and repotrectinib over third-generation lorlatinib for NSCLC with ALK F1174C/L/V mutations.

Balasundaram A et al.

Frontiers in Molecular Biosciences, 2023

Durable clinical response to ALK tyrosine kinase inhibitors in ALK-rearranged non-small cell lung cancer: a case report.

Hu H et al.

Translational Cancer Research, 2022

Genetic landscape of patients with ALK-rearranged non-small-cell lung cancer (NSCLC) and response to ceritinib in ASCEND-1 study.

Tan DS et al.

Lung Cancer (amsterdam, Netherlands), 2022

Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies.

Christopoulos P et al.

Translational Lung Cancer Research, 2021

34164264 (PubMed )
Supplement: tlcr-10-05-2118-supplementary.pdf

Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA.

Dietz S et al.

Ebiomedicine, 2020

ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer.

Shaw AT et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2019

Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy.

Santarpia M et al.

Drug Design, Development and Therapy, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."