Varaico: Literature-Extracted Genetic Variants

Gene:ALK
Variant:p.L861R
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ALK

NM_004304.5:p.L861R

Associated Papers

Comparison of next-generation sequencing and cobas EGFR mutation test v2 in detecting EGFR mutations.

Murakami S et al.

Thoracic Cancer, 2022

Identifying a wide range of actionable variants using capture-based ultra-deep targeted sequencing in treatment-naive patients with primary lung adenocarcinoma.

Chen L et al.

International Journal of Clinical and Experimental Pathology, 2020

Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors and Non-Small Cell Lung Cancer (NSCLC) - Advances in Molecular Diagnostic Techniques to Facilitate Targeted Therapy.

Ghafoor Q et al.

Pathology Oncology Research : Por, 2018

Compound EGFR mutation is frequently detected with co-mutations of actionable genes and associated with poor clinical outcome in lung adenocarcinoma.

Kim EY et al.

Cancer Biology & Therapy, 2016

EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIs.

Kobayashi Y et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2015

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Lindeman NI et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2013

Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer.

Vignot S et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2013

Common and rare EGFR and KRAS mutations in a Dutch non-small-cell lung cancer population and their clinical outcome.

Kerner GS et al.

Plos One, 2013

Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status.

An SJ et al.

Plos One, 2012

Targeted Sequencing of Circulating Cell Free DNA Can Be Used to Monitor Therapeutic Efficacy of Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer Patients.

Chiou CC et al.

Cancer Genomics & Proteomics, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."