Associated Papers
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication.
Adele R et al.
Jci Insight, 2024
Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies.
Lessard S et al.
Bmc Genomics, 2024
Whole exome sequencing identifies a novel mutation in Annexin A4 that is associated with recurrent spontaneous abortion.
Ye Q et al.
Frontiers in Medicine, 2024
The Landscape of Point Mutations in Human Protein Coding Genes Leading to Pregnancy Loss.
Maksiutenko EM et al.
International Journal of Molecular Sciences, 2023
Genetics and epigenetics of chronic rhinosinusitis.
Lal D et al.
The Journal of Allergy and Clinical Immunology, 2023
Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population.
Belkadi A et al.
Cell Genomics, 2023
Exome variants associated with asthma and allergy.
Wjst M
Scientific Reports, 2022
Computational and Experimental Analysis of Genetic Variants.
Prokop JW et al.
Comprehensive Physiology, 2022
Genetics and Epigenetics of Nasal Polyposis: A Systematic Review.
Martin MJ et al.
Journal of Investigational Allergology & Clinical Immunology, 2021
Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches.
Quintero-Ronderos P et al.
Reproductive Sciences (thousand Oaks, Calif.), 2020
Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations.
Sprissler R et al.
Cancers, 2020
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
Kristjansson RP et al.
Nature Genetics, 2019
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Ferreira MA et al.
Nature Genetics, 2017
Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.
Horn T et al.
Biochimica Et Biophysica Acta, 2013
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Kleinstein SE et al.
Genes, Chromosomes & Cancer, 2013
Functional characterization of genetic enzyme variations in human lipoxygenases.
Horn T et al.
Redox Biology, 2013
Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population.
Zhao J et al.
Journal of Molecular Neuroscience : Mn, 2012
Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.
Samanta S et al.
Plos One, 2012
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
Schurmann K et al.
The Journal of Biological Chemistry, 2011
Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.
Zhang K et al.
Heart and Vessels, 2010
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Hersberger M et al.
Atherosclerosis, 2009
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Assimes TL et al.
Atherosclerosis, 2008