Associated Papers
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
Shimakura K et al.
Biochemical and Biophysical Research Communications, 2021
Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.
Sato K et al.
The Journal of Biological Chemistry, 2018
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation.
Otomo A et al.
Febs Letters, 2011
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
Tudor EL et al.
The Journal of Biological Chemistry, 2005
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