Associated Papers
Population-specific putative causal variants shape quantitative traits.
Koyama S et al.
Nature Genetics, 2024
ACE Phenotyping in Human Blood and Tissues: Revelation of ACE Outliers and Sex Differences in ACE Sialylation.
Enyedi EE et al.
Biomedicines, 2024
The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation.
Abu-Farha M et al.
Cells, 2023
Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant.
Abu-Farha M et al.
Metabolites, 2023
Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4.
Landfors F et al.
Journal of Lipid Research, 2023
Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8.
Oldoni F et al.
The Journal of Clinical Endocrinology and Metabolism, 2021
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nielsen JB et al.
Nature Communications, 2020
Variants of Lipid-Related Genes in Adult Japanese Patients with Severe Hypertriglyceridemia.
Matsunaga A et al.
Journal of Atherosclerosis and Thrombosis, 2020
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima-Media Thickness in T2DM.
Guo C et al.
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020
Spectrum of Mutations and Long-Term Clinical Outcomes in Genetic Chylomicronemia Syndromes.
D'Erasmo L et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia.
Tarugi P et al.
Journal of Biomedical Research, 2019
Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus.
Ghasemi H et al.
Journal of Clinical Laboratory Analysis, 2019
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.
Natarajan P et al.
Nature Communications, 2018
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease.
El-Lebedy D
Cardiovascular Diabetology, 2018
Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus.
Cannon ME et al.
G3 (bethesda, Md.), 2017
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.
Dewey FE et al.
Science (new York, N.y.), 2016
The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.
Lim CH et al.
Oncotarget, 2016
The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.
Hanson RL et al.
Molecular Genetics and Metabolism, 2016
ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits.
Abu-Farha M et al.
Lipids in Health and Disease, 2016
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
Peloso GM et al.
American Journal of Human Genetics, 2014
Atypical angiopoietin-like protein that regulates ANGPTL3.
Quagliarini F et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012
High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant.
Liu J et al.
Journal of Clinical Lipidology, 0