Associated Papers
Common gene mutations in 103 authenticated colorectal cancer cell lines.
Kranjec C et al.
Oncogenesis, 2026
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A et al.
Biorxiv : the Preprint Server for Biology, 2025
JPI-547, a Dual Inhibitor of PARP/Tankyrase, Shows Antitumor Activity Against Pancreatic Cancers with Homologous Recombination Repair Deficiency or Wnt-Addiction.
Oh KS et al.
International Journal of Biological Sciences, 2025
Colibactin mutational signatures in NTHL1 tumor syndrome and MUTYH associated polyposis patients.
Terlouw D et al.
Genes, Chromosomes & Cancer, 2024
Comprehensive genomic characterization of sporadic synchronous colorectal cancer: Implications for treatment optimization and clinical outcome.
Yang LP et al.
Cell Reports. Medicine, 2023
Mutational landscape of plasma cell-free DNA identifies molecular features associated with therapeutic response in patients with colon cancer. A pilot study.
Cervena K et al.
Mutagenesis, 2021
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M et al.
Molecular Cell, 2021
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.
Kleeman SO et al.
Gut, 2020
Serum starvation enhances nonsense mutation readthrough.
Wittenstein A et al.
Journal of Molecular Medicine (berlin, Germany), 2019
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.
Schumacher D et al.
Plos Genetics, 2019
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
Menon M et al.
Scientific Reports, 2019
The role of APC in WNT pathway activation in serrated neoplasia.
Borowsky J et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2018
APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
Tanaka N et al.
Molecular Cancer Therapeutics, 2017
Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells.
Floquet C et al.
Plos One, 2011
Familial adenomatous polyposis: experience from a study of 1164 unrelated german polyposis patients.
Friedl W et al.
Hereditary Cancer in Clinical Practice, 2005