Varaico: Literature-Extracted Genetic Variants

Gene:APEX1
Variant:p.E96Q
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APEX1

NM_001641.4:p.E96Q

Associated Papers

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

Ashour ME et al.

Biorxiv : the Preprint Server for Biology, 2025

Structural basis for APE1 processing DNA damage in the nucleosome.

Weaver TM et al.

Nature Communications, 2022

Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance.

McNeill DR et al.

Mutagenesis, 2020

Damage sensor role of UV-DDB during base excision repair.

Jang S et al.

Nature Structural & Molecular Biology, 2019

Sperm-Specific Glyceraldehyde-3-Phosphate Dehydrogenase - An Evolutionary Acquisition of Mammals.

Muronetz VI et al.

Biochemistry. Biokhimiia, 2015

Human apurinic/apyrimidinic endonuclease 1.

Li M et al.

Antioxidants & Redox Signaling, 2014

Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.

Tsutakawa SE et al.

The Journal of Biological Chemistry, 2013

MD simulation and experimental evidence for Mg²+ binding at the B site in human AP endonuclease 1.

Oezguen N et al.

Bioinformation, 2011

Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy.

Lipton AS et al.

Journal of the American Chemical Society, 2008

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.

McNeill DR et al.

Molecular Cancer Research : Mcr, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."