Associated Papers
Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer.
Kpenu EK et al.
Research Square, 2025
Structural basis for APE1 processing DNA damage in the nucleosome.
Weaver TM et al.
Nature Communications, 2022
The role of active-site amino acid residues in the cleavage of DNA and RNA substrates by human apurinic/apyrimidinic endonuclease APE1.
Alekseeva IV et al.
Biochimica Et Biophysica Acta. General Subjects, 2020
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
Tsutakawa SE et al.
The Journal of Biological Chemistry, 2013
Pre-steady-state kinetic characterization of the AP endonuclease activity of human AP endonuclease 1.
Maher RL et al.
The Journal of Biological Chemistry, 2007
Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function.
Xi T et al.
Genomics, 2004
Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.
Rothwell DG et al.
Nucleic Acids Research, 2000
Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.
Shen MR et al.
Cancer Research, 1998
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