Varaico: Literature-Extracted Genetic Variants

Gene:APEX1
Variant:p.R237C
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APEX1

NM_001641.4:p.R237C

Associated Papers

The Link Between Human Alkyladenine DNA Glycosylase and Cancer Development.

Kladova OA et al.

International Journal of Molecular Sciences, 2025

Probing altered enzyme activity in the biochemical characterization of cancer.

Adam MAA et al.

Bioscience Reports, 2022

Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins.

Kladova OA et al.

International Journal of Molecular Sciences, 2020

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity.

Cabral LKD et al.

Cancers, 2020

Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.

Caffrey PJ et al.

Mutagenesis, 2020

Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance.

McNeill DR et al.

Mutagenesis, 2020

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.

Li J et al.

Oncotarget, 2018

Base excision repair of oxidative DNA damage: from mechanism to disease.

Whitaker AM et al.

Frontiers in Bioscience (landmark Edition), 2017

Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.

Illuzzi JL et al.

Environmental and Molecular Mutagenesis, 2017

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.

Lirussi L et al.

Oncotarget, 2016

Reduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (APE1) Variants on Nucleosomes: IDENTIFICATION OF ACCESS RESIDUES.

Hinz JM et al.

The Journal of Biological Chemistry, 2015

Human apurinic/apyrimidinic endonuclease 1.

Li M et al.

Antioxidants & Redox Signaling, 2014

Functional assessment of population and tumor-associated APE1 protein variants.

Illuzzi JL et al.

Plos One, 2013

Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.

Kirkali G et al.

Plos One, 2013

Base excision repair and cancer.

Wallace SS et al.

Cancer Letters, 2012

Variation in base excision repair capacity.

Wilson DM et al.

Mutation Research, 2011

Functional characterization of Ape1 variants identified in the human population.

Hadi MZ et al.

Nucleic Acids Research, 2000

Molecular and structural characterization of disease-associated APE1 polymorphisms.

Whitaker AM et al.

Dna Repair, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."