Associated Papers
HAMMER: Hairpin-based APOBEC3A-mediated mRNA editing reporter.
Chen Y et al.
Biorxiv : the Preprint Server for Biology, 2026
APOBEC3A drives deaminase mutagenesis in human gastric epithelium.
An Y et al.
Genome Research, 2025
APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats.
Brown RE et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability.
Kawale AS et al.
Science Advances, 2024
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.
Carpenter MA et al.
Plos Genetics, 2023
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.
Harjes S et al.
Nature Communications, 2023
DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
Naumann JA et al.
International Journal of Molecular Sciences, 2023
APOBEC3A Catalytic Inactivity Mutation Induces Tertiary Structure Destabilization.
Jones KFM et al.
Acs Medicinal Chemistry Letters, 2023
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Zhao K et al.
Molecular Cancer Research : Mcr, 2021
Creating RNA Specific C-to-U Editase from APOBEC3A by Separation of Its Activities on DNA and RNA Substrates.
Tang G et al.
Acs Synthetic Biology, 2021
An extended APOBEC3A mutation signature in cancer.
Langenbucher A et al.
Nature Communications, 2021
Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks.
Stewart JA et al.
Nucleic Acids Research, 2020
Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.
Sakhtemani R et al.
The Journal of Biological Chemistry, 2019
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.
Buisson R et al.
Science (new York, N.y.), 2019
APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
Buisson R et al.
Cancer Research, 2017
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Shi K et al.
Nature Structural & Molecular Biology, 2017
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Bohn MF et al.
Structure (london, England : 1993), 2015
Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity.
Horn AV et al.
Nucleic Acids Research, 2014
Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties.
Mitra M et al.
Nucleic Acids Research, 2014
APOBEC3B is an enzymatic source of mutation in breast cancer.
Burns MB et al.
Nature, 2013