Associated Papers
Exonic Variation and Its Clinical Impact in 7221 Old Order Amish.
Mitchell BD et al.
American Journal of Medical Genetics. Part A, 2025
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Selvaraj MS et al.
Genome Biology, 2025
The role of protective genetic variants in modulating epigenetic aging.
Bejaoui Y et al.
Geroscience, 2025
Investigating telomere length in progeroid syndromes: implications for aging disorders.
Srour L et al.
Aging, 2025
Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants.
Hu Y et al.
Clinical Epigenetics, 2025
Arab founder variants: Contributions to clinical genomics and precision medicine.
AlAbdi L et al.
Med (new York, N.y.), 2025
Burden of Mendelian disorders in a large Middle Eastern biobank.
Aamer W et al.
Genome Medicine, 2024
Understanding Hypertriglyceridemia: Integrating Genetic Insights.
Alves M et al.
Genes, 2024
Missense variants in SORT1 are associated with LDL-C in an Amish population.
Mitok KA et al.
Journal of Lipid Research, 2023
Genetics of metabolic traits in Greenlanders.
Thuesen ACB et al.
Danish Medical Journal, 2023
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.
Wang Y et al.
American Journal of Human Genetics, 2023
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.
Wang Y et al.
Medrxiv : the Preprint Server for Health Sciences, 2023
Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
Selvaraj MS et al.
Nature Communications, 2022
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations.
Taskinen MR et al.
Jci Insight, 2022
Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project.
Cong PK et al.
Nature Communications, 2022
An Amish founder population reveals rare-population genetic determinants of the human lipidome.
Montasser ME et al.
Communications Biology, 2022
Genetics and regulation of HDL metabolism.
Kardassis D et al.
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 2022
Ethnic differences in ApoC-III concentration and the risk of cardiovascular disease: No evidence for the cardioprotective role of rare/loss of function APOC3 variants in non-Europeans.
Rout M et al.
American Heart Journal Plus : Cardiology Research and Practice, 2022
Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia.
Xu Y et al.
Frontiers in Cardiovascular Medicine, 2022
Unravelling lipoprotein metabolism with stable isotopes: tracing the flow.
Ying Q et al.
Metabolism: Clinical and Experimental, 2021
APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups.
Goyal S et al.
Lipids in Health and Disease, 2021
Volanesorsen for treatment of familial chylomicronemia syndrome.
Lazarte J et al.
Expert Review of Cardiovascular Therapy, 2021
Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.
Read RW et al.
Frontiers in Genetics, 2021
Common APOC3 variants are associated with circulating ApoC-III and VLDL cholesterol but not with total apolipoprotein B and coronary artery disease.
Silbernagel G et al.
Atherosclerosis, 2020
Low cholesterol syndrome and drug development.
Handhle A et al.
Current Opinion in Cardiology, 2020
Triglycerides and remnant cholesterol associated with risk of aortic valve stenosis: Mendelian randomization in the Copenhagen General Population Study.
Kaltoft M et al.
European Heart Journal, 2020
Xanthomas Can Be Misdiagnosed and Mistreated in Homozygous Familial Hypercholesterolemia Patients: A Call for Increased Awareness Among Dermatologists and Health Care Practitioners.
Alnouri F et al.
Global Heart, 2020
Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias.
Dron JS et al.
Bmc Medical Genomics, 2020
APOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic Inflammation in Nonalcoholic Fatty Liver Disease.
Xu QY et al.
Biomed Research International, 2020
Sequence analysis and variant identification at the APOC3 gene locus indicates association of rs5218 with BMI in a sample of Kuwaiti's.
Malalla ZH et al.
Lipids in Health and Disease, 2019
Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease.
Dai W et al.
Lipids in Health and Disease, 2019
The GenomeAsia 100K Project enables genetic discoveries across Asia.
Unknown Author
Nature, 2019
Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes.
Capalbo A et al.
Plos Genetics, 2019
Genomics of disease risk in globally diverse populations.
Gurdasani D et al.
Nature Reviews. Genetics, 2019
Investigation of new candidate genes in retinoblastoma using the TruSight One "clinical exome" gene panel.
Akdeniz D et al.
Molecular Genetics & Genomic Medicine, 2019
Genetics, Dyslipidemia, and Cardiovascular Disease: New Insights.
Stein R et al.
Current Cardiology Reports, 2019
Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD.
Taskinen MR et al.
Current Atherosclerosis Reports, 2019
Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism.
Reyes-Soffer G et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Genetics of metabolic traits in Greenlanders: lessons from an isolated population.
Andersen MK et al.
Journal of Internal Medicine, 2018
Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree.
Kember RL et al.
Translational Psychiatry, 2018
Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.
Zhou Y et al.
Journal of Lipid Research, 2018
Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels.
Crawford DC et al.
Bmc Medical Genomics, 2018
Genetics of Subclinical Coronary Atherosclerosis.
Bielak LF et al.
Current Genetic Medicine Reports, 2018
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.
Natarajan P et al.
Nature Communications, 2018
APOC3 Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation- and Meta-Analyses of 137 895 Individuals.
Wulff AB et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation.
Hsueh WC et al.
Circulation. Cardiovascular Genetics, 2017